Kim N P, Ovchinnikov I V, Guliamov D S, Maevskii E I
Tashkent Branch, USSR Surgery Research Centre, Academy of Medical Sciences.
Cor Vasa. 1989;31(4):306-11.
In 145 patients with severe mitral stenosis the levels of energy substrates and adenile nucleotides were determined in biopsy samples from the left atrial appendage obtained during mitral commissurotomy. Patients with the latest stage (stage IV according to Bakulev and Damir's classification) of mitral stenosis displayed, in comparison with stage III patients, activation of aerobic oxidation of glucose, lactate and succinate, together with a moderate reduction in myocardial glucose, lactate and pyruvate levels. ATP content and myocardial adenile nucleotide pool did not change with progression of the disease.
在145例重度二尖瓣狭窄患者中，于二尖瓣分离术期间从左心耳获取活检样本，测定其中能量底物和腺嘌呤核苷酸的水平。与Ⅲ期患者相比，处于二尖瓣狭窄最晚期（根据巴库列夫和达米尔分类法为Ⅳ期）的患者，其葡萄糖、乳酸盐和琥珀酸盐的有氧氧化被激活，同时心肌中的葡萄糖、乳酸盐和丙酮酸水平略有降低。随着疾病进展，三磷酸腺苷（ATP）含量和心肌腺嘌呤核苷酸池并未发生变化。
