Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
J Am Coll Cardiol. 2017 Jan 3;69(1):73-82. doi: 10.1016/j.jacc.2016.09.979.
The association of coronary heart disease (CHD) and human immunodeficiency virus (HIV) infection has been well recognized for many years. The etiology of the increased prevalence of CHD in HIV-infected populations is the result of complex interactions among the viral infection, host factors, traditional risk factors, and therapies for HIV. As the HIV population is living longer, largely attributable to combination antiretroviral therapy, there is concern about the effect of the rising prevalence of CHD on morbidity and mortality, as well its effect on health systems around the world. This review will highlight the epidemiological evidence linking HIV infection and CHD. It will also focus on our current understanding of the pathogenesis and factors associated with HIV infection and CHD. In addition, the review will highlight modes of presentation and management strategies for mitigating risk and treatment of HIV-positive patients presenting with CHD.
多年来，人们已经充分认识到冠心病（CHD）与人类免疫缺陷病毒（HIV）感染之间的关联。HIV 感染者中 CHD 流行率增加的病因是病毒感染、宿主因素、传统危险因素和 HIV 治疗之间复杂相互作用的结果。随着 HIV 人群的寿命延长，这在很大程度上归因于联合抗逆转录病毒疗法，人们担心 CHD 流行率的上升对发病率和死亡率的影响，以及对全球卫生系统的影响。这篇综述将重点介绍将 HIV 感染与 CHD 联系起来的流行病学证据。它还将侧重于我们目前对 HIV 感染和 CHD 相关发病机制和因素的理解。此外，该综述将重点介绍 HIV 阳性患者出现 CHD 时的表现模式和管理策略，以降低风险和治疗。
