Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
J Am Coll Cardiol. 2017 Jan 3;69(1):83-91. doi: 10.1016/j.jacc.2016.09.977.
Human immunodeficiency virus (HIV)-associated heart disease encompasses a broad spectrum of diseases. HIV infection may involve the pericardium, myocardium, coronary arteries, pulmonary vasculature, and valves, as well as the systemic vasculature. Access to combination antiretroviral therapy, as well as health resources, has had a significant influence on the prevalence and severity of the effects on each cardiac structure. Investigations over the recent past have improved our understanding of the epidemiology and pathophysiology of HIV-associated cardiovascular disease. This review will focus on our current understanding of pathogenesis and risk factors associated with HIV infection and heart disease, and it will discuss relevant advances in diagnosis and management of these conditions.
人类免疫缺陷病毒（HIV）相关性心脏病包含广泛的疾病谱。HIV 感染可能累及心包、心肌、冠状动脉、肺血管和瓣膜以及全身血管。联合抗逆转录病毒疗法的应用以及健康资源的可及性对每种心脏结构的影响的流行率和严重程度都产生了重大影响。最近的研究提高了我们对 HIV 相关性心血管疾病的流行病学和病理生理学的认识。这篇综述将重点关注我们目前对 HIV 感染和心脏病相关发病机制和危险因素的理解，并讨论这些疾病的诊断和管理方面的相关进展。
