Paleczny Bartłomiej, Siennicka Agnieszka, Ponikowski Piotr, Ponikowska Beata
Department of Physiology, Wroclaw Medical University, Wroclaw, Poland; Department of Cardiology, Centre for Heart Diseases, 4th Military Hospital, Wroclaw, Poland.
Department of Physiology, Wroclaw Medical University, Wroclaw, Poland; Department of Cardiology, Centre for Heart Diseases, 4th Military Hospital, Wroclaw, Poland.
Auton Neurosci. 2017 Mar;203:108-112. doi: 10.1016/j.autneu.2016.12.008. Epub 2016 Dec 29.
Evaluation of sympathetic baroreflex (sBR) function in humans requires intra-neural recording of muscle sympathetic nerve activity (MSNA) by microneurography.
We proposed noninvasive approach for the evaluation of sBR function by applying the threshold-analysis (traditionally, based on MSNA) to systemic vascular resistance (SVR) measurement by photoplethysmography.
METHODS & RESULTS: In nine healthy subjects (5M; age: 25±5y), the threshold-analysis was calculated twice: using MSNA and SVR. Both methods yield comparable results in men (T(burst-vs.-svr): CV=8.8%, r>0.9; Slope: CV=30.1%; r>0.9), but not in women.
SVR-based threshold-analysis is feasible in healthy young subjects and provides a promising alternative to the traditional MSNA-based approach.
评估人类交感神经压力反射（sBR）功能需要通过微神经ography术对肌肉交感神经活动（MSNA）进行神经内记录。
我们提出了一种非侵入性方法，通过将阈值分析（传统上基于MSNA）应用于通过光电容积描记法测量的全身血管阻力（SVR）来评估sBR功能。
在9名健康受试者（5名男性；年龄：25±5岁）中，阈值分析计算了两次：使用MSNA和SVR。两种方法在男性中产生了可比的结果（爆发与svr的阈值：CV = 8.8%，r>0.9；斜率：CV = 30.1%；r>0.9），但在女性中并非如此。
基于SVR的阈值分析在健康年轻受试者中是可行的，并为传统的基于MSNA的方法提供了一个有前景的替代方案。
