Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.
Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.
Biochim Biophys Acta Mol Basis Dis. 2017 Mar;1863(3):764-769. doi: 10.1016/j.bbadis.2016.12.016. Epub 2017 Jan 2.
Several hypotheses have been raised about the dual role of histamine in neurological disorders, and evidences have shown its crucial involvement in the modulation of microglia-mediated neuroinflammation. Previously, we reported that the administration of histamine induces a deleterious effect by promoting a pro-inflammatory phenotype on microglia that in turn compromises dopaminergic neuronal survival. Contrary, under lipopolysaccharide challenge, histamine inhibits the injurious effect of microglia-mediated inflammation, protecting dopaminergic neurons, suggesting that the modulation of microglial activity is dependent on the environmental context. Thus, histamine and/or histamine receptor agonists may serve to develop new therapeutic approaches to overcome neurodegenerative disorders.
已经提出了几种关于组胺在神经紊乱中的双重作用的假说，并且有证据表明它在调节小胶质细胞介导的神经炎症中起着关键作用。之前，我们报道了组胺的给药通过促进小胶质细胞的促炎表型而产生有害作用，进而损害多巴胺能神经元的存活。相反，在脂多糖刺激下，组胺抑制小胶质细胞介导的炎症的损伤作用，保护多巴胺能神经元，这表明小胶质细胞活性的调节依赖于环境背景。因此，组胺和/或组胺受体激动剂可能有助于开发新的治疗方法来克服神经退行性疾病。
