Shen Xia, Zhao Zhenyu, Luo Xuan, Wang Hao, Hu Benxiang, Guo Zihu
College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, Shaanxi 712046, China.
Bioinformatics Center, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
Evid Based Complement Alternat Med. 2016;2016:9146378. doi: 10.1155/2016/9146378. Epub 2016 Dec 12.
Mental disorder is a group of systemic diseases characterized by a variety of physical and mental discomfort, which has become the rising threat to human life. Herbal medicines were used to treat mental disorders for thousand years in China in which the molecular mechanism is not yet clear. To systematically explain the mechanisms of SiNiSan (SNS) formula on the treatment of mental disorders. A systems pharmacology method, with ADME screening, targets prediction, and DAVID enrichment analysis, was employed as the principal approach in our study. 60 active ingredients of SNS formula and 187 mental disorders related targets were discovered to have interactions with them. Furthermore, the enrichment analysis of drug-target network showed that SNS probably acts through "multi-ingredient, multitarget, and multisystems" holistic coordination in different organs pattern by indirectly regulating the nutritional and metabolic pathway even their serial complications. Our research provides a reference for the molecular mechanism of medicinal herbs in the treatment of mental disease on a systematic level. Hopefully, it will also provide a theoretical basis for the discovery of lead compounds of natural medicines for other diseases based on traditional medicine.
精神障碍是一组以各种身心不适为特征的系统性疾病，已成为对人类生命日益增长的威胁。在中国，草药用于治疗精神障碍已有数千年历史，但其分子机制尚不清楚。为了系统地解释四逆散（SNS）方剂治疗精神障碍的机制，本研究采用了一种系统药理学方法，包括ADME筛选、靶点预测和DAVID富集分析。发现SNS方剂的60种活性成分与187个精神障碍相关靶点存在相互作用。此外，药物-靶点网络的富集分析表明，SNS可能通过“多成分、多靶点、多系统”在不同器官模式下的整体协调作用，间接调节营养和代谢途径甚至其系列并发症。我们的研究为草药治疗精神疾病的分子机制提供了系统层面的参考。希望它也能为基于传统医学发现其他疾病天然药物的先导化合物提供理论依据。
