Tanenbaum L, Taplin D, Lavelle C, Akers W A, Rosenberg M J, Carmargo G
Syntex Research, Palo Alto, California.
Cutis. 1989 Oct;44(4):344-7.
Sulconazole nitrate 1 percent cream, a new imidazole derivative, was tested in 117 Colombian Army soldiers with tinea cruris/corporis under hot, humid conditions. The results of two clinical trials demonstrate that sulconazole applied once daily was as effective as clotrimazole applied twice daily. After three weeks of therapy 100 percent of the patients treated either once or twice daily with sulconazole showed negative findings on potassium hydroxide preparations and cultures from lesions. Although sulconazole was well tolerated and caused no adverse reactions, four of twenty-seven clotrimazole-treated patients showed reactions consisting of erosive primary irritation. Sulconazole nitrate 1 percent cream appears to be highly effective in the treatment of tinea cruris/corporis when applied once or twice daily and may be very useful in hot and humid conditions where contact irritation reactions occur more often.
1%硝酸硫康唑乳膏是一种新型咪唑衍生物，在炎热潮湿环境下对117名患有股癣/体癣的哥伦比亚陆军士兵进行了测试。两项临床试验结果表明，每日使用一次硫康唑与每日使用两次克霉唑效果相同。治疗三周后，每日使用一次或两次硫康唑治疗的患者，在病变部位的氢氧化钾制剂和培养物检查中均显示阴性结果。虽然硫康唑耐受性良好且未引起不良反应，但27名接受克霉唑治疗的患者中有4人出现了糜烂性原发性刺激反应。1%硝酸硫康唑乳膏每日使用一次或两次治疗股癣/体癣似乎非常有效，在炎热潮湿且接触性刺激反应更易发生的环境中可能非常有用。
