Bogaert H, Cordero C, Ollague W, Savin R C, Shalita A R, Zaias N
J Int Med Res. 1986;14(4):210-6. doi: 10.1177/030006058601400408.
In separate multicentre, randomized, double-blind clinical trials, 1% ciclopirox olamine cream was compared with its cream vehicle and with 1% clotrimazole cream as treatment for tinea corporis and tinea cruris. Patients who demonstrated clinical and mycological findings consistent with the diagnoses of tinea corporis or tinea cruris were included in the study. Clinical and mycological evaluations were made pretreatment, at the end of each of the four weeks of treatment, and weekly for the two weeks immediately following cessation of treatment. In both studies, use of ciclopirox olamine cream resulted in demonstrable improvements after the first week of therapy and in complete clinical and mycological clearing in two thirds of the patients at the end of the treatment period. These results were maintained through the two-week drug-free observation period that followed the end of treatment. Statistically, the results with ciclopirox olamine cream were significantly better than those with the vehicle and were equivalent to those with clotrimazole cream. All treatments were well tolerated.
在两项独立的多中心、随机、双盲临床试验中，将1%环吡酮胺乳膏与其基质乳膏以及1%克霉唑乳膏作为体癣和股癣的治疗药物进行比较。临床表现和真菌学检查结果符合体癣或股癣诊断的患者被纳入研究。在治疗前、治疗四周中的每周末以及治疗结束后紧接着的两周内每周进行临床和真菌学评估。在两项研究中，使用环吡酮胺乳膏在治疗第一周后即有明显改善，在治疗期末三分之二的患者实现了临床和真菌学完全清除。这些结果在治疗结束后的两周无药观察期内得以维持。从统计学角度看，环吡酮胺乳膏的治疗结果显著优于基质乳膏，且与克霉唑乳膏相当。所有治疗耐受性良好。
