Presland Richard B
Richard B Presland, Department of Oral Health Sciences, School of Dentistry, University of Washington, Seattle, WA 98195, United States.
World J Transplant. 2016 Dec 24;6(4):608-619. doi: 10.5500/wjt.v6.i4.608.
Chronic graft--host disease (cGVHD) is the leading cause of long-term morbidity and mortality following allogeneic hematopoietic stem cell transplantation. It presents as a chronic inflammatory and sclerotic autoimmune-like condition that most frequently affects the skin, oral mucosa, liver, eyes and gastrointestinal tract. Both clinical and animal studies have shown that multiple T cell subsets including Th1, Th2, Th17, T follicular helper cells and regulatory T-cells play some role in cGVHD development and progression; B cells also play an important role in the disease including the production of antibodies to HY and nuclear antigens that can cause serious tissue damage. An array of cytokines and chemokines produced by different types of immune cells also mediate tissue inflammation and damage of cGVHD target tissues such as the skin and oral cavity. Many of these same immune regulators have been studied as candidate cGVHD biomarkers. Recent studies suggest that some of these biomarkers may be useful for determining disease prognosis and planning long-term clinical follow-up of cGVHD patients.
慢性移植物抗宿主病（cGVHD）是异基因造血干细胞移植后长期发病和死亡的主要原因。它表现为一种慢性炎症和硬化性自身免疫样疾病，最常累及皮肤、口腔黏膜、肝脏、眼睛和胃肠道。临床和动物研究均表明，包括Th1、Th2、Th17、滤泡辅助性T细胞和调节性T细胞在内的多个T细胞亚群在cGVHD的发生和发展中发挥了一定作用；B细胞在该疾病中也起着重要作用，包括产生针对HY和核抗原的抗体，这些抗体可导致严重的组织损伤。不同类型免疫细胞产生的一系列细胞因子和趋化因子也介导了cGVHD靶组织（如皮肤和口腔）的组织炎症和损伤。许多这些相同的免疫调节因子已作为cGVHD生物标志物的候选物进行了研究。最近的研究表明，其中一些生物标志物可能有助于确定疾病预后并规划cGVHD患者的长期临床随访。
