Numan Onur, Vural Fisun, Aka Nurettin, Alpay Murat, Coskun Ayse Deniz Erturk
Department of Obstetrics and Gynaecology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
North Clin Istanb. 2015 Dec 25;2(3):203-209. doi: 10.14744/nci.2015.55376. eCollection 2015.
Toxoplasma gondii, Rubella, Cytomegalovirus and Herpes simplex viruses are microorganisms that cause congenital infections and they are called briefly as TORCH. There is an ongoing argument for the screening of reproductive age women due to the high cost of tests. For a test to be used in screening, prevalence of disease in this population should be known. The aim of this study was to investigate TORCH seroprevalence among women attending a teaching hospital in Istanbul.
A total of 1101 patients attending outpatient clinic of Obstetric Care Clinic of Haydarpasa Training and Research Hospital affiliated to Association of Istanbul Northern Anatolia Public Hospitals between September 2013 to January 2015 and their laboratory data were evaluated retrospectively. We investigated Ig G and M seropositivity rates against TORCH.
The age of the patients ranged between 17-47 years with a mean age of 30.3±5.8 years. Pregnant population had 99.5% anti-CMV Ig G (+), 94.2% anti-Rubella Ig G (+), 31% anti-Toxoplasma Ig G (+). Seroprevalence for Anti IgM was 0.5% for CMV, 0.2% for rubella.
The screening for Toxoplasma gondii may be suggested since the prevalence is not high in our population. The screening of CMV is not meaningful, due to high seroprevalence. Although seroprevalence of rubella is also high, it may be suggested for preconception vaccination especially in women above 20 years of age born prior to National Vaccination Programme.
弓形虫、风疹病毒、巨细胞病毒和单纯疱疹病毒是导致先天性感染的微生物,简称为TORCH。由于检测成本高昂,对于育龄妇女的筛查一直存在争议。要将一项检测用于筛查,应了解该人群中的疾病患病率。本研究的目的是调查伊斯坦布尔一家教学医院就诊女性的TORCH血清阳性率。
回顾性评估2013年9月至2015年1月期间在隶属于伊斯坦布尔北安纳托利亚公立医院协会的海达尔帕萨培训与研究医院产科护理门诊就诊的1101例患者及其实验室数据。我们调查了针对TORCH的IgG和IgM血清阳性率。
患者年龄在17 - 47岁之间,平均年龄为30.3±5.8岁。孕妇人群中抗巨细胞病毒IgG阳性率为99.5%,抗风疹IgG阳性率为94.2%,抗弓形虫IgG阳性率为31%。抗IgM的血清阳性率,巨细胞病毒为0.5%,风疹为0.2%。
由于我们人群中弓形虫患病率不高,可能建议进行筛查。由于血清阳性率高,巨细胞病毒筛查无意义。虽然风疹的血清阳性率也很高,但对于在国家疫苗接种计划之前出生的20岁以上女性,可能建议进行孕前接种疫苗。