Kaygusuz Oğuzhan, Kaygusuz Meruyert, Dodurga Yavuz, Seçme Mücahit, Herken Emine Nur, Gezer Kutret
Department of Biology, Faculty of Science and Arts, Pamukkale University, P.O. BOX 20001, Denizli, Turkey.
Denizli Vocational School of Technical Sciences, Pamukkale University, Denizli, Turkey.
Cytotechnology. 2017 Feb;69(1):135-144. doi: 10.1007/s10616-016-0045-4. Epub 2017 Jan 5.
The present investigation was undertaken to evaluate the antimicrobial and antioxidant activities of the wild edible mushroom Agaricus lanipes, and also to investigate its cytotoxicity and potential and possible apoptotic effect against the A549 lung cancer cell line in in vitro conditions. Total antioxidant capacity, total phenolic content, total oxidant status, total antioxidant status, lipid hydroperoxides, and total free -SH levels of A. lanipes were found to be 4.55 mg T/g, 14.6 mg GA equivalent/g, 3.10 mg HO equivalent/g, 2.25 mg HO equivalent/g, and 1.90 µmol/g, respectively. The methanolic extract of A. lanipes had relatively strong antimicrobial activity against seven tested microorganism strains. It also had high anti-proliferative potency and strong pro-apoptotic effects, and this mushroom used as a daily nutrient could be a source for new drug developments and treatment in cancer therapies, and could be a guide for studies in this area.
本研究旨在评估野生可食用蘑菇毛柄蘑菇的抗菌和抗氧化活性，并研究其在体外条件下对A549肺癌细胞系的细胞毒性、潜能及可能的凋亡作用。毛柄蘑菇的总抗氧化能力、总酚含量、总氧化剂状态、总抗氧化状态、脂质氢过氧化物和总游离巯基水平分别为4.55毫克 Trolox 当量/克、14.6毫克没食子酸当量/克、3.10毫克过氧化氢当量/克、2.25毫克过氧化氢当量/克和1.90微摩尔/克。毛柄蘑菇的甲醇提取物对七种受试微生物菌株具有较强的抗菌活性。它还具有高抗增殖效力和强促凋亡作用，这种作为日常营养物质的蘑菇可能是癌症治疗新药开发和治疗的来源，也可为该领域的研究提供指导。
