Gudasheva T A, Grigoriev V V, Koliasnikova K N, Zamoyski V L, Seredenin S B
Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia.
Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432, Russia.
Dokl Biochem Biophys. 2016 Nov;471(1):387-389. doi: 10.1134/S160767291606003X. Epub 2017 Jan 6.
We have previously shown that neuropeptide cycloprolylglycine (CPG) increases the content of brain-derived neurotrophic factor (BDNF) in the culture of neuronal cells under normal conditions and in pathology. This is the first study to show that CPG at a physiological concentration of 10 M significantly enhances the transmembrane AMPA currents in rat cerebellar Purkinje cells. Thus, CPG is a positive endogenous modulator of AMPA receptors. It was assumed that the neuropsychotropic effects of CPG are implemented as a result of BDNF accumulation after the activation of AMPA receptors by this neuropeptide.
我们之前已经表明，神经肽环丙基甘氨酸（CPG）在正常条件下和病理状态下均可增加神经元细胞培养物中脑源性神经营养因子（BDNF）的含量。这是第一项表明生理浓度为10 μM的CPG可显著增强大鼠小脑浦肯野细胞中跨膜AMPA电流的研究。因此，CPG是AMPA受体的内源性正向调节剂。据推测，CPG的神经精神作用是由于该神经肽激活AMPA受体后BDNF积累而实现的。
