Zakusov Research Institute of Pharmacology, Moscow, Russia.
Dokl Biochem Biophys. 2022 Dec;507(1):264-267. doi: 10.1134/S1607672922060047. Epub 2023 Feb 14.
Previously, we have shown that the endogenous neuropeptide cycloprolylglycine (CPG) is the positive modulator of AMPA receptors and revealed the dependence of its anxiolytic and antihypoxic action on BDNF/Trk signaling. In the present work, we for the first time conducted in vitro experiments using the AMPA receptor blockers DNQX and GYKI 52466 and the Trk receptor blocker K252a. It is shown that the neuroprotective effect of CPG depends on the activation of both AMPA and Trk receptors.
先前，我们已经表明内源性神经肽环丙基甘氨酸 (CPG) 是 AMPA 受体的正调节剂，并揭示了其抗焦虑和抗缺氧作用对 BDNF/Trk 信号的依赖性。在本工作中，我们首次使用 AMPA 受体阻滞剂 DNQX 和 GYKI 52466 以及 Trk 受体阻滞剂 K252a 进行了体外实验。结果表明，CPG 的神经保护作用依赖于 AMPA 和 Trk 受体的激活。
