Woldu Solomon L, Bagrodia Aditya, Lotan Yair
Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
BJU Int. 2017 Mar;119(3):371-380. doi: 10.1111/bju.13760. Epub 2017 Jan 24.
Non-muscle-invasive bladder cancer (NMIBC) represents the vast majority of bladder cancer diagnoses, but this definition represents a spectrum of disease with a variable clinical course, notable for significant risk of recurrence and potential for progression. Management involves risk-adapted strategies of cystoscopic surveillance and intravesical therapy with the goal of bladder preservation when safe to do so. Multiple organizational guidelines exist to help practitioners manage this complicated disease process, but adherence to management principles among practising urologists is reportedly low. We review four major organizational guidelines on NMIBC: the American Urological Association (AUA)/Society of Urologic Oncology (SUO), European Association of Urology (EAU), National Comprehensive Cancer Network (NCCN), and National Institute for Health and Care Excellence (NICE) guidelines.
非肌层浸润性膀胱癌(NMIBC)占膀胱癌诊断病例的绝大多数,但这一定义涵盖了一系列临床病程各异的疾病,其显著特点是复发风险高且有进展的可能。治疗策略包括根据风险调整的膀胱镜监测和膀胱内灌注治疗,目的是在安全的情况下保留膀胱。现有多个组织制定的指南来帮助临床医生管理这一复杂的疾病过程,但据报道,执业泌尿科医生对管理原则的遵循程度较低。我们回顾了关于NMIBC的四项主要组织指南:美国泌尿外科学会(AUA)/泌尿肿瘤学会(SUO)、欧洲泌尿外科学会(EAU)、美国国立综合癌症网络(NCCN)以及英国国家卫生与临床优化研究所(NICE)指南。