Beger H G, Bittner R, Schölzel E, Büchler M, Block S, Malfertheiner P
Chirurgie. 1989;115(3):193-201.
In 122 patients with severe chronic pancreatitis and inflammatory enlargement of the head of the pancreas a duodenum-preserving resection of the pancreatic head was performed. Postoperative hospitalization was 16 days in median, the frequency of re-operation was 4.9%. In the early postoperative phase one patient died and hospital mortality amounted to 0.8%. Following a medium follow-up period of 4.2 years (min. 6 months, max. 15 years) 7 patients died (late mortality 4.9%). 77% of the patients were completely free of abdominal pain, 84% went back to their previous occupation. During the follow-up period in 81% of the patients the glucose metabolism was unchanged, in 13% it deteriorated, and in 5% it improved permanently; 80% of the patients had a marked increase in weight averaging 8.7 kg. Compared to the Whipple procedure the duodenum-preserving resection of the head of the pancreas spares the patient with chronic pancreatitis a gastric resection, the duodenectomy, and the resection of the extrahepatic bile ducts. The limited operative intervention at the head of the pancreas in terms of a subtotal resection and the preservation of the duodenum explains the low early and late postoperative morbidity and mortality.
对122例患有严重慢性胰腺炎且胰头炎性肿大的患者实施了保留十二指肠的胰头切除术。术后住院时间中位数为16天,再次手术率为4.9%。术后早期有1例患者死亡,医院死亡率为0.8%。经过4.2年的中位随访期(最短6个月,最长15年),有7例患者死亡(晚期死亡率4.9%)。77%的患者完全没有腹痛,84%的患者恢复了之前的工作。在随访期间,81%的患者糖代谢未改变,13%的患者糖代谢恶化,5%的患者糖代谢永久改善;80%的患者体重显著增加,平均增加8.7千克。与惠普尔手术相比,保留十二指肠的胰头切除术使慢性胰腺炎患者免于胃切除、十二指肠切除和肝外胆管切除。胰头的有限手术干预,即次全切除并保留十二指肠,解释了术后早期和晚期的低发病率和死亡率。