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The Fourth Law of Behavior Genetics.行为遗传学第四定律。
Curr Dir Psychol Sci. 2015 Jul 1;24(4):304-312. doi: 10.1177/0963721415580430.
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The validity of the multi-informant approach to assessing child and adolescent mental health.多 informant 方法评估儿童和青少年心理健康的有效性。 （注：这里“informant”不太明确准确含义，可根据上下文进一步确定合适译法，比如“信息提供者”等 ）
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Longitudinal Stability of Genetic and Environmental Influences on Irritability: From Childhood to Young Adulthood.遗传和环境因素对易激惹性的纵向稳定性：从儿童期到青年期。
Am J Psychiatry. 2015 Jul;172(7):657-64. doi: 10.1176/appi.ajp.2015.14040509. Epub 2015 Apr 23.
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A genetically informed study of the longitudinal relation between irritability and anxious/depressed symptoms.一项关于易怒与焦虑/抑郁症状纵向关系的基因学研究。
J Am Acad Child Adolesc Psychiatry. 2015 May;54(5):377-84. doi: 10.1016/j.jaac.2015.02.010. Epub 2015 Feb 28.
5
Oppositional defiant disorder (ODD), the forerunner of alcohol dependence: a controlled study.对立违抗障碍（ODD），酒精依赖的先驱：一项对照研究。
Asian J Psychiatr. 2014 Oct;11:8-12. doi: 10.1016/j.ajp.2014.03.006. Epub 2014 Mar 21.
6
Identifying the irritability dimension of ODD: Application of a modified bifactor model across five large community samples of children.识别对立违抗障碍的易激惹维度：改良双因素模型在五个大型儿童社区样本中的应用
J Abnorm Psychol. 2014 Nov;123(4):841-51. doi: 10.1037/a0037898. Epub 2014 Oct 13.
7
Irritable and defiant sub-dimensions of ODD: their stability and prediction of internalizing symptoms and conduct problems from adolescence to young adulthood.对立违抗性障碍的易激惹和违抗亚维度：从青少年到青年期的稳定性及内化症状和行为问题的预测
J Abnorm Child Psychol. 2015 Apr;43(3):407-21. doi: 10.1007/s10802-014-9908-3.
8
Dimensions of Oppositional Defiant Disorder in young children: heterotypic continuity with anxiety and depression.幼儿对立违抗障碍的维度：与焦虑和抑郁的异型连续性
J Abnorm Child Psychol. 2014 Aug;42(6):937-51. doi: 10.1007/s10802-014-9853-1.
9
Developmental continuity of oppositional defiant disorder subdimensions at ages 8, 10, and 13 years and their distinct psychiatric outcomes at age 16 years.对立违抗障碍亚维度在 8 岁、10 岁和 13 岁时的发展连续性及其在 16 岁时的不同精神科结局。
J Am Acad Child Adolesc Psychiatry. 2013 Sep;52(9):961-9. doi: 10.1016/j.jaac.2013.06.013. Epub 2013 Aug 1.
10
Dimensions of oppositionality in a Brazilian community sample: testing the DSM-5 proposal and etiological links.巴西社区样本中的对立维度：测试 DSM-5 提案及病因学关联。
J Am Acad Child Adolesc Psychiatry. 2013 Apr;52(4):389-400.e1. doi: 10.1016/j.jaac.2013.01.004.

对立违抗性障碍维度：遗传影响及后续精神病理学风险

Oppositional defiant disorder dimensions: genetic influences and risk for later psychopathology.

作者信息

Mikolajewski Amy J, Taylor Jeanette, Iacono William G

机构信息

Department of Psychiatry and Behavioral Sciences, School of Medicine, Tulane University, New Orleans, LA, USA.

Department of Psychology, Florida State University, Tallahassee, FL, USA.

出版信息

J Child Psychol Psychiatry. 2017 Jun;58(6):702-710. doi: 10.1111/jcpp.12683. Epub 2017 Jan 6.

DOI:10.1111/jcpp.12683
PMID:28059443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5438275/
Abstract

BACKGROUND

This study was undertaken to determine how well two oppositional defiant disorder (ODD) dimensions (irritable and headstrong/hurtful) assessed in childhood predict late adolescent psychopathology and the degree to which these outcomes can be attributed to genetic influences shared with ODD dimensions.

METHODS

Psychopathology was assessed via diagnostic interviews of 1,225 twin pairs at ages 11 and 17.

RESULTS

Consistent with hypotheses, the irritable dimension uniquely predicted overall internalizing problems, whereas the headstrong/hurtful dimension uniquely predicted substance use disorder symptoms. Both dimensions were predictive of antisocial behavior and overall externalizing problems. The expected relationships between the irritable dimension and specific internalizing disorders were not found. Twin modeling showed that the irritable and headstrong/hurtful dimensions were related to late adolescent psychopathology symptoms through common genetic influences.

CONCLUSIONS

Symptoms of ODD in childhood pose a significant risk for various mental health outcomes in late adolescence. Further, common genetic influences underlie the covariance between irritable symptoms in childhood and overall internalizing problems in late adolescence, whereas headstrong/hurtful symptoms share genetic influences with substance use disorder symptoms. Antisocial behavior and overall externalizing share common genetic influences with both the irritable and headstrong/hurtful dimensions.

摘要

背景

本研究旨在确定童年期评估的对立违抗障碍（ODD）的两个维度（易怒和任性/伤人）对青少年晚期精神病理学的预测能力，以及这些结果可归因于与ODD维度共享的遗传影响的程度。

方法

通过对1225对双胞胎在11岁和17岁时进行诊断访谈来评估精神病理学。

结果

与假设一致，易怒维度独特地预测了总体内化问题，而任性/伤人维度独特地预测了物质使用障碍症状。两个维度都能预测反社会行为和总体外化问题。未发现易怒维度与特定内化障碍之间的预期关系。双胞胎模型显示，易怒和任性/伤人维度通过共同的遗传影响与青少年晚期精神病理学症状相关。

结论

童年期ODD症状对青少年晚期的各种心理健康结果构成重大风险。此外，童年期易怒症状与青少年晚期总体内化问题之间的协方差有共同的遗传影响，而任性/伤人症状与物质使用障碍症状有共同的遗传影响。反社会行为和总体外化与易怒和任性/伤人维度都有共同的遗传影响。