Zhuang Jun, Ng Lydia, Williams Derric, Valley Matthew, Li Yang, Garrett Marina, Waters Jack
Allen Institute for Brain Science, Seattle, United States.
Elife. 2017 Jan 6;6:e18372. doi: 10.7554/eLife.18372.
Visual perception and behavior are mediated by cortical areas that have been distinguished using architectonic and retinotopic criteria. We employed fluorescence imaging and GCaMP6 reporter mice to generate retinotopic maps, revealing additional regions of retinotopic organization that extend into barrel and retrosplenial cortices. Aligning retinotopic maps to architectonic borders, we found a mismatch in border location, indicating that architectonic borders are not aligned with the retinotopic transition at the vertical meridian. We also assessed the representation of visual space within each region, finding that four visual areas bordering V1 (LM, P, PM and RL) display complementary representations, with overlap primarily at the central hemifield. Our results extend our understanding of the organization of mouse cortex to include up to 16 distinct retinotopically organized regions.
视觉感知和行为由根据结构和视网膜拓扑标准区分的皮质区域介导。我们使用荧光成像和GCaMP6报告基因小鼠来生成视网膜拓扑图，揭示了延伸至桶状皮质和压后皮质的视网膜拓扑组织的其他区域。将视网膜拓扑图与结构边界对齐后，我们发现边界位置不匹配，这表明结构边界与垂直子午线处的视网膜拓扑转换不一致。我们还评估了每个区域内视觉空间的表征，发现与V1相邻的四个视觉区域（LM、P、PM和RL）呈现互补表征，主要在中央半视野重叠。我们的结果扩展了我们对小鼠皮质组织的理解，使其包括多达16个不同的视网膜拓扑组织区域。
