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单节段减压与多节段减压对多节段腰椎管狭窄症疗效的影响:腰椎脊柱疗效研究(LSOS)数据分析

The Influence of Single-level Versus Multilevel Decompression on the Outcome in Multisegmental Lumbar Spinal Stenosis: Analysis of the Lumbar Spinal Outcome Study (LSOS) Data.

作者信息

Ulrich Nils H, Burgstaller Jakob M, Held Ulrike, Winklhofer Sebastian, Farshad Mazda, Pichierri Giuseppe, Steurer Johann, Porchet François

机构信息

Department of Orthopedics and Neurosurgery, Spine Center, Schulthess Clinic.

Horten Centre for Patient Oriented Research and Knowledge Transfer.

出版信息

Clin Spine Surg. 2017 Dec;30(10):E1367-E1375. doi: 10.1097/BSD.0000000000000469.

Abstract

STUDY DESIGN

This is prospective multicenter cohort study.

OBJECTIVE

To assess whether patients with confirmed multisegmental lumbar spinal stenosis benefit more from a single-level or a multilevel decompression.

SUMMARY OF BACKGROUND DATA

In multisegmental lumbar spinal stenotic cases, the decision as to how many levels of stenosis need to be operated to achieve the best possible clinical outcome is still unknown and remains a controversy between spine surgeons.

MATERIALS AND METHODS

Patients of the Swiss Lumbar Stenosis Outcome Study (LSOS) with confirmed multisegmental LSS undergoing first-time decompression without fusion were enrolled in this study. The main outcomes of this study were Spinal Stenosis Measure (SSM) symptoms and function over time, measured at baseline, 6, 12, and 24 months follow-up. Further outcomes of interest were changes in SSM, numeric rating scale, feeling thermometer, the EQ-5D-EL, and the Roland and Morris disability questionnaire from baseline to 6, 12, and 24 months.

RESULTS

After 12 months, a total of 141 patients met the inclusion criteria; of these, 33 (23%) underwent a single-level and 108 (77%) a multilevel decompression. Multilevel decompression was associated with a significantly less favorable SSM symptoms and function score, respectively, as compared with single-level decompression. In all further outcomes of interest single-level as well as multilevel patients improved over time.

CONCLUSIONS

Our study showed that in multisegmental stenotic cases a single-level decompression was associated with a significantly more favorable SSM symptoms and function score, respectively, as compared with multilevel decompression. This study provides evidence that in multisegmental stenotic cases a single-level decompression might be sufficient to improve patient's symptoms and function.

摘要

研究设计

这是一项前瞻性多中心队列研究。

目的

评估确诊为多节段腰椎管狭窄症的患者从单节段减压还是多节段减压中获益更多。

背景数据总结

在多节段腰椎管狭窄症病例中,对于需要手术减压多少节段才能获得最佳临床效果的决策仍不明确,并且仍然是脊柱外科医生之间的一个争议点。

材料与方法

瑞士腰椎管狭窄症结局研究(LSOS)中确诊为多节段腰椎管狭窄症且首次接受非融合减压手术的患者被纳入本研究。本研究的主要结局指标是随时间变化的椎管狭窄测量(SSM)症状和功能,在基线、随访6个月、12个月和24个月时进行测量。其他感兴趣的结局指标是从基线到6个月、12个月和24个月时SSM、数字评分量表、感觉温度计、EQ - 5D - EL以及罗兰和莫里斯残疾问卷的变化。

结果

12个月后,共有141例患者符合纳入标准;其中,33例(23%)接受了单节段减压,108例(77%)接受了多节段减压。与单节段减压相比,多节段减压分别与明显更差的SSM症状和功能评分相关。在所有其他感兴趣的结局指标中,单节段和多节段患者随时间均有改善。

结论

我们的研究表明,在多节段狭窄病例中,与多节段减压相比,单节段减压分别与明显更有利的SSM症状和功能评分相关。本研究提供了证据,表明在多节段狭窄病例中,单节段减压可能足以改善患者的症状和功能。

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