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胚胎小脑组织移植修复脊髓横断损伤的实验研究

[Experimental study on embryo cerebellar tissue transplantation in repairing transection injury of spinal cord].

作者信息

Nan L Z

出版信息

Zhonghua Wai Ke Za Zhi. 1989 Apr;27(4):247-9, 255.

PMID:2805997
Abstract

Transplantation of cerebellar tissue to the transection part of the spinal cord was performed on 48 dogs. Among them, 35 dogs were transplanted with cultured cerebellar tissue, 7 of which resumed standing and walking ability, 13 dogs were transplanted with embryo cerebellar tissue and 7 resumed standing and walking (58.3%). In the control group of 8 dogs, no recover was found. Histological examination and HRP reaction showed that (1) embryo cerebellar tissue may prevent the scar formation and neuroglia proliferation; (2) some neurofibers existed in the scar tissue between the two ends of transected spinal cord; (3) the connection of the grafting material and the host was established by special target.

摘要

对48只犬进行了小脑组织移植到脊髓横断部位的手术。其中,35只犬移植了培养的小脑组织,其中7只恢复了站立和行走能力;13只犬移植了胚胎小脑组织,7只恢复了站立和行走(58.3%)。在8只犬的对照组中,未发现恢复情况。组织学检查和HRP反应表明:(1)胚胎小脑组织可能防止瘢痕形成和神经胶质细胞增生;(2)脊髓横断两端之间的瘢痕组织中存在一些神经纤维;(3)移植材料与宿主通过特殊的靶点建立连接。

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