Turbes C C
Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA.
Biomed Sci Instrum. 1997;34:351-6.
The structural changes seen in the transected spinal cord followed by transplantation of the distal ends (neuroma) of intercostal nerve inserted into the spinal cord proximal and distal to the transection lesion site. This activates CNS axonal regeneration. 2,3,4 These changes refer to the plasticity in the nervous system following damage to the spinal cord. There is regeneration and growth and synapotogenesis and remodeling of synaptic connections, development of reflex activity in the denervated cord. Nerve growth factors and neurotrophic factors sustain and maintain a degree of functional integrity of structural neural circuitry. 2,3,4,13 The end result is standing, stepping, and reflex walking in 28 female mature dogs. 2,3,4,5 Electrical stimulation of the anastomosed intercostal nerves resulted in hind limb movements and recording of the electromyograms of the contracting muscles. Twenty-six control dogs and animals with behavioral depression are unable to follow rehabilitative procedures developed muscle atrophy, ankylosis of joints, decrease in bone density, decrease in reflex activity of the spinal cord distal to the transection. 2,3,4,5
在横断脊髓后，将肋间神经远端（神经瘤）移植到横断损伤部位近端和远端的脊髓中，可观察到结构变化。这会激活中枢神经系统轴突再生。2,3,4这些变化指的是脊髓损伤后神经系统的可塑性。存在再生、生长、突触发生以及突触连接的重塑，失神经支配脊髓中反射活动的发展。神经生长因子和神经营养因子维持并保持结构神经回路一定程度的功能完整性。2,3,4,13最终结果是28只成年雌性犬能够站立、行走和进行反射性步行。2,3,4,5对吻合的肋间神经进行电刺激会导致后肢运动，并记录收缩肌肉的肌电图。26只对照犬和有行为抑制的动物无法遵循康复程序，出现肌肉萎缩、关节强直、骨密度降低、横断部位远端脊髓反射活动减弱。2,3,4,5
