Lee Kang Won, Kim Jung Yong, Chin Hee Seung, Seo Kyoung Yul, Kim Tae-Im, Jung Ji Won
*Department of Ophthalmology and Inha Vision Science Laboratory, Inha University School of Medicine, Incheon, South Korea; and †The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, South Korea.
Cornea. 2017 Feb;36(2):189-195. doi: 10.1097/ICO.0000000000001033.
We aimed to compare the tear meniscus measurements using strip meniscometry (SM) and Keratograph5M (K5M) between 3 subtypes of dry eye disease patient groups, classified according to the presence of meibomian gland dysfunction (MGD), and normal subjects.
We enrolled 145 eyes from 145 subjects and measured the tear meniscus using SM and K5M, tear film breakup time, ocular surface staining, and ocular surface disease index; the Schirmer test; and examined lid margins and meibomian glands. Correlation of tear meniscus parameters with other parameters and efficacy of the 2 measurements were evaluated.
The SM and K5M results were significantly lower in the non-Sjögren syndrome aqueous-deficient dry eye (non-SS ADDE) with and without MGD groups than in the MGD-only group and normal subjects. The SM or K5M results correlated with each other and with other ocular surface parameters. The area under the curve (AUC) of the SM and K5M results was 0.637 (P = 0.012) and 0.610 (P = 0.042), respectively. Except for the MGD group, the AUC of the SM and K5M results were 0.721 (P < 0.001) and 0.694 (P = 0.001), respectively. The AUC of SM and K5M were 0.947 (P < 0.001) and 0.784 (P = 0.002), differentiating non-SS ADDE-only patients from those with normal eyes.
Tear meniscus measurements using SM and K5M can compensate for detection of aqueous-deficient components of dry eye. These results should be interpreted according to the presence or absence of MGD.
我们旨在比较使用带状泪液半月板测量法（SM）和角膜地形图仪5M（K5M）对根据睑板腺功能障碍（MGD）的有无分类的3种亚型干眼患者组和正常受试者进行泪液半月板测量的结果。
我们纳入了145名受试者的145只眼睛，使用SM和K5M测量泪液半月板、泪膜破裂时间、眼表染色和眼表疾病指数；进行泪液分泌试验；并检查睑缘和睑板腺。评估泪液半月板参数与其他参数的相关性以及两种测量方法的有效性。
伴有和不伴有MGD的非干燥综合征性水液缺乏型干眼（非SS ADDE）组的SM和K5M结果显著低于仅MGD组和正常受试者。SM或K5M结果彼此之间以及与其他眼表参数相关。SM和K5M结果的曲线下面积（AUC）分别为0.637（P = 0.012）和0.610（P = 0.042）。除MGD组外，SM和K5M结果的AUC分别为0.721（P < 0.001）和0.694（P = 0.001）。SM和K5M的AUC分别为0.947（P < 0.001）和0.784（P = 0.002），可区分仅患有非SS ADDE的患者和正常眼睛的患者。
使用SM和K5M进行泪液半月板测量可以补充对干眼水液缺乏成分的检测。这些结果应根据MGD的有无进行解释。
