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靶向视网膜神经节细胞的恢复。

Targeting retinal ganglion cell recovery.

作者信息

Crowston J G, Fahy E T, Fry L, Trounce I A, van Wijngaarden P, Petrou S, Chrysostomou V

机构信息

Royal Victorian Eye and Ear Hospital, Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia.

Centre for Eye Research Australia and Department of Surgery, University of Melbourne Royal Victorian Eye and Ear Hospital, Melbourne, Australia.

出版信息

Eye (Lond). 2017 Feb;31(2):196-198. doi: 10.1038/eye.2016.281. Epub 2017 Jan 6.

DOI:10.1038/eye.2016.281
PMID:28060359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5306466/
Abstract

Accumulating evidence from experimental and clinical studies suggest that retinal ganglion cells at least in the earlier stages of glaucoma have the capacity to recover function following periods of functional loss. The capacity for recovery may be negatively impacted by advancing age but can be boosted by interventions such as diet restriction and exercise.

摘要

来自实验和临床研究的越来越多的证据表明,至少在青光眼的早期阶段,视网膜神经节细胞在经历功能丧失期后有恢复功能的能力。恢复能力可能会受到年龄增长的负面影响,但可以通过饮食限制和运动等干预措施得到增强。

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本文引用的文献

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Exercise reverses age-related vulnerability of the retina to injury by preventing complement-mediated synapse elimination via a BDNF-dependent pathway.运动通过一条依赖脑源性神经营养因子(BDNF)的途径,防止补体介导的突触消除,从而逆转与年龄相关的视网膜对损伤的易感性。
Aging Cell. 2016 Dec;15(6):1082-1091. doi: 10.1111/acel.12512. Epub 2016 Sep 9.
2
Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate.运动通过酮体β-羟基丁酸的作用促进脑源性神经营养因子(BDNF)的表达。
Elife. 2016 Jun 2;5:e15092. doi: 10.7554/eLife.15092.
3
Reversible structural and functional changes after intraocular pressure reduction in patients with glaucoma.青光眼患者眼压降低后可逆的结构和功能变化。
Graefes Arch Clin Exp Ophthalmol. 2016 Jun;254(6):1159-66. doi: 10.1007/s00417-016-3321-2. Epub 2016 Mar 19.
4
Trabeculectomy Can Improve Long-Term Visual Function in Glaucoma.小梁切除术可改善青光眼的长期视力功能。
Ophthalmology. 2016 Jan;123(1):117-28. doi: 10.1016/j.ophtha.2015.09.027. Epub 2015 Oct 24.
5
Effect of subconjunctival glucose on retinal ganglion cell survival in experimental retinal ischaemia and contrast sensitivity in human glaucoma.结膜下注射葡萄糖对实验性视网膜缺血中视网膜神经节细胞存活及人类青光眼患者对比敏感度的影响
Clin Exp Ophthalmol. 2016 Jan-Feb;44(1):24-32. doi: 10.1111/ceo.12581. Epub 2015 Aug 12.
6
An acute intraocular pressure challenge to assess retinal ganglion cell injury and recovery in the mouse.通过急性眼压挑战评估小鼠视网膜神经节细胞损伤及恢复情况。
Exp Eye Res. 2015 Dec;141:3-8. doi: 10.1016/j.exer.2015.03.006. Epub 2015 Mar 7.
7
Forced exercise protects the aged optic nerve against intraocular pressure injury.强迫运动可保护老年视神经免受眼内压损伤。
Neurobiol Aging. 2014 Jul;35(7):1722-5. doi: 10.1016/j.neurobiolaging.2014.01.019. Epub 2014 Jan 23.
8
Glucose-induced temporary visual recovery in primary open-angle glaucoma: a double-blind, randomized study.葡萄糖诱导原发性开角型青光眼的暂时视力恢复:一项双盲、随机研究。
Ophthalmology. 2014 Jun;121(6):1203-11. doi: 10.1016/j.ophtha.2013.12.011. Epub 2014 Feb 1.
9
Intraocular pressure lowering is associated with an increase in the photopic negative response (PhNR) amplitude in glaucoma and ocular hypertensive eyes.眼压降低与青光眼和高眼压眼中的明视负向反应(PhNR)振幅增加有关。
Invest Ophthalmol Vis Sci. 2013 Mar 15;54(3):1913-9. doi: 10.1167/iovs.12-10869.
10
Impact of aging and diet restriction on retinal function during and after acute intraocular pressure injury.衰老和饮食限制对急性眼内压损伤期间和之后视网膜功能的影响。
Neurobiol Aging. 2012 Jun;33(6):1126.e15-25. doi: 10.1016/j.neurobiolaging.2011.11.026. Epub 2012 Jan 2.