靶向视网膜神经节细胞的恢复。
Targeting retinal ganglion cell recovery.
作者信息
Crowston J G, Fahy E T, Fry L, Trounce I A, van Wijngaarden P, Petrou S, Chrysostomou V
机构信息
Royal Victorian Eye and Ear Hospital, Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia.
Centre for Eye Research Australia and Department of Surgery, University of Melbourne Royal Victorian Eye and Ear Hospital, Melbourne, Australia.
出版信息
Eye (Lond). 2017 Feb;31(2):196-198. doi: 10.1038/eye.2016.281. Epub 2017 Jan 6.
Abstract
Accumulating evidence from experimental and clinical studies suggest that retinal ganglion cells at least in the earlier stages of glaucoma have the capacity to recover function following periods of functional loss. The capacity for recovery may be negatively impacted by advancing age but can be boosted by interventions such as diet restriction and exercise.
摘要
来自实验和临床研究的越来越多的证据表明，至少在青光眼的早期阶段，视网膜神经节细胞在经历功能丧失期后有恢复功能的能力。恢复能力可能会受到年龄增长的负面影响，但可以通过饮食限制和运动等干预措施得到增强。
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Aging Cell. 2016 Dec;15(6):1082-1091. doi: 10.1111/acel.12512. Epub 2016 Sep 9.
2
Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate.运动通过酮体β-羟基丁酸的作用促进脑源性神经营养因子（BDNF）的表达。
Elife. 2016 Jun 2;5:e15092. doi: 10.7554/eLife.15092.
3
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