Shimoyama R, Fujita-Yamaguchi Y, Boden G
Research Division, Hokkaido Red Cross Blood Center, Sapporo, Japan.
Diabetes Res Clin Pract. 1989;7 Suppl 1:S59-66. doi: 10.1016/0168-8227(89)90089-2.
Sera and immunoglobulin G from 10/104 diabetic patients (five with insulin-dependent, five with non-insulin-dependent diabetes) were found to contain antibodies that bound 125I-labelled purified human placental insulin receptors. Nine of these sera failed to inhibit insulin binding to cultured rat hepatocytes and did not stimulate glucose oxidation in rat adipocytes. Only one serum modestly inhibited insulin binding and stimulated glucose oxidation. These results suggest that sera from nine of these 104 diabetics contained a new type of anti-insulin receptor antibodies (AIRA) which bound to a locus different from the insulin binding site, and that only one of the 104 diabetic sera contained a low titer of conventional AIRA which could cause a clinical condition not distinguishable from ordinary non-insulin-dependent diabetes.
在104名糖尿病患者（5名胰岛素依赖型、5名非胰岛素依赖型糖尿病患者）中，发现10份血清和免疫球蛋白G含有能与125I标记的纯化人胎盘胰岛素受体结合的抗体。其中9份血清不能抑制胰岛素与培养的大鼠肝细胞的结合，也不能刺激大鼠脂肪细胞中的葡萄糖氧化。只有一份血清能适度抑制胰岛素结合并刺激葡萄糖氧化。这些结果表明，这104名糖尿病患者中的9名患者的血清含有一种新型抗胰岛素受体抗体（AIRA），该抗体与不同于胰岛素结合位点的位点结合，并且这104份糖尿病血清中只有一份含有低滴度的传统AIRA，这种传统AIRA可能导致一种与普通非胰岛素依赖型糖尿病无法区分的临床病症。
