Rylander Melanie, Brinton John T, Sabel Allison L, Mehler Philip S, Gaudiani Jennifer L
a Department of Medicine , University of Colorado , Denver , Colorado , USA.
b ACUTE Center for Eating Disorders at Denver Health , Denver , Colorado , USA.
Eat Disord. 2017 Jul-Sep;25(4):345-357. doi: 10.1080/10640266.2016.1269555. Epub 2017 Jan 6.
This study examines adult patients with severe, life-threatening anorexia nervosa who were admitted to an inpatient, medical stabilization unit between October 1, 2008 and December 31, 2014. Specifically, the study compares anorexia nervosa, binge purge subtype (AN-BP) and anorexia nervosa, restricting subtype (AN-R) on admission measures, hospital course, and outcomes. Of the 232 patients, 46% (N = 108) had AN-BP. Patients with AN-R manifested a higher frequency of underweight-mediated medical complications, including bone marrow dysfunction, hepatic dysfunction, and hypoglycemia. Understanding the pathophysiologic differences between severe AN-R and AN-BP is essential to understanding the abnormalities seen on clinical presentation, guiding appropriate clinical treatment, and predicting medical complications during refeeding.
本研究调查了2008年10月1日至2014年12月31日期间入住住院医疗稳定病房的患有严重、危及生命的神经性厌食症的成年患者。具体而言，该研究比较了神经性厌食症的暴饮暴食清除亚型（AN-BP）和神经性厌食症的限制亚型（AN-R）在入院指标、住院过程和结局方面的情况。在这232名患者中，46%（N = 108）患有AN-BP。AN-R患者出现体重过轻介导的医学并发症的频率更高，包括骨髓功能障碍、肝功能障碍和低血糖。了解重度AN-R和AN-BP之间的病理生理差异对于理解临床表现中出现的异常、指导适当的临床治疗以及预测再喂养期间的医学并发症至关重要。
