Bin Guo, Wang Tianfu, Zeng Hongwu, He Xiaoming, Li Feng, Zhang Jian, Huang Bingsheng
National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, Guangdong, P.R, China.
Department of Radiology, Shenzhen Children's Hospital, Shenzhen, Guangdong, P.R, China.
PLoS One. 2017 Jan 6;12(1):e0169076. doi: 10.1371/journal.pone.0169076. eCollection 2017.
We aimed to identify the consistent regions of gray matter volume (GMV) abnormalities in idiopathic generalized epilepsy (IGE), and to study the difference of GMV abnormalities among IGE subsyndromes by applying activation likelihood estimation (ALE) meta-analysis.
A systematic review of VBM studies on GMV of patients with absence epilepsy (AE), juvenile myoclonic epilepsy (JME), IGE and controls indexed in PubMed and ScienceDirect from January 1999 to June 2016 was conducted. A total of 12 IGE studies, including 7 JME and 3 AE studies, were selected. Meta-analysis was performed on these studies by using the pooled and within-subtypes analysis (www.brainmap.org). Based on the above results, between-subtypes contrast analysis was carried out to detect the abnormal GMV regions common in and unique to each subtype as well.
IGE demonstrated significant GMV increase in right ventral lateral nucleus (VL) and right medial frontal gyrus, and significant GMV decrease in bilateral pulvinar. For JME, significant GMV increase was seen in right medial frontal gyrus, right anterior cingulate cortex (ACC), while significant GMV decrease was found in right pulvinar. In AE, the most significant GMV increase was found in right VL, and slight GMV reduction was seen in right medial dorsal nucleus, right subcallosal gyrus, left caudate and left precuneus. No overlapped and unique regions with significant GMV abnormalities were found between JME and AE.
This meta-analysis demonstrated that thalamo-frontal network was a structure with significant GMV abnormality in IGE, and the IGE subsyndromes showed different GMV abnormal regions. These observations may provide instructions on the clinical diagnosis of IGE.
我们旨在通过应用激活可能性估计（ALE）元分析来确定特发性全身性癫痫（IGE）中灰质体积（GMV）异常的一致区域，并研究IGE亚综合征之间GMV异常的差异。
对1999年1月至2016年6月在PubMed和ScienceDirect上索引的关于失神癫痫（AE）、青少年肌阵挛癫痫（JME）、IGE患者及对照的GMV的体素形态学（VBM）研究进行系统综述。共选择了12项IGE研究，包括7项JME研究和3项AE研究。使用汇总分析和亚型内分析（www.brainmap.org）对这些研究进行元分析。基于上述结果，进行亚型间对比分析以检测每个亚型共有的和独特的GMV异常区域。
IGE显示右侧腹外侧核（VL）和右侧额内侧回的GMV显著增加，双侧丘脑枕的GMV显著减少。对于JME，右侧额内侧回、右侧前扣带回皮质（ACC）的GMV显著增加，而右侧丘脑枕的GMV显著减少。在AE中，右侧VL的GMV增加最为显著，右侧背内侧核、右侧胼胝体下回、左侧尾状核和左侧楔前叶的GMV略有减少。JME和AE之间未发现具有显著GMV异常的重叠和独特区域。
这项元分析表明丘脑-额叶网络是IGE中具有显著GMV异常的结构，并且IGE亚综合征表现出不同的GMV异常区域。这些观察结果可能为IGE的临床诊断提供指导。
