源自脑异常和深部脑刺激的广义癫痫网络。

A generalized epilepsy network derived from brain abnormalities and deep brain stimulation.

作者信息

Ji Gong-Jun, Fox Michael D, Morton-Dutton Mae, Wang Yingru, Sun Jinmei, Hu Panpan, Chen Xingui, Jiang Yubao, Zhu Chunyan, Tian Yanghua, Zhang Zhiqiang, Akkad Haya, Nordberg Janne, Joutsa Juho, Torres Diaz Cristina V, Groppa Sergiu, Gonzalez-Escamilla Gabriel, Toledo Maria de, Dalic Linda J, Archer John S, Selway Richard, Stavropoulos Ioannis, Valentin Antonio, Yang Jimmy, Isbaine Faical, Gross Robert E, Park Sihyeong, Gregg Nicholas M, Cukiert Arthur, Middlebrooks Erik H, Dosenbach Nico U F, Turner Joseph, Warren Aaron E L, Chua Melissa M J, Cohen Alexander L, Larivière Sara, Neudorfer Clemens, Horn Andreas, Sarkis Rani A, Bubrick Ellen J, Fisher Robert S, Rolston John D, Wang Kai, Schaper Frederic L W V J

机构信息

Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui Province, 230032, China.

Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, 230032, China.

出版信息

Nat Commun. 2025 Mar 24;16(1):2783. doi: 10.1038/s41467-025-57392-7.

DOI:10.1038/s41467-025-57392-7

PMID:40128186

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11933423/

Abstract

Idiopathic generalized epilepsy (IGE) is a brain network disease, but the location of this network and its relevance for treatment remain unclear. We combine the locations of brain abnormalities in IGE (131 coordinates from 21 studies) with the human connectome to identify an IGE network. We validate this network by showing alignment with structural brain abnormalities previously identified in IGE and brain areas activated by generalized epileptiform discharges in simultaneous electroencephalogram-functional magnetic resonance imaging. The topography of the IGE network aligns with brain networks involved in motor control and loss of consciousness consistent with generalized seizure semiology. To investigate therapeutic relevance, we analyze data from 21 patients with IGE treated with deep brain stimulation (DBS) for generalized seizures. Seizure frequency reduced a median 90% after DBS and stimulation sites intersect an IGE network peak in the centromedian nucleus of the thalamus. Together, this study helps unify prior findings in IGE and identify a brain network target that can be tested in clinical trials of brain stimulation to control generalized seizures.

摘要

特发性全身性癫痫（IGE）是一种脑网络疾病，但其网络位置及其与治疗的相关性仍不清楚。我们将IGE中脑异常的位置（来自21项研究的131个坐标）与人类连接组相结合，以识别一个IGE网络。我们通过显示其与先前在IGE中确定的脑结构异常以及同步脑电图-功能磁共振成像中由全身性癫痫样放电激活的脑区的一致性来验证这个网络。IGE网络的拓扑结构与参与运动控制和意识丧失的脑网络一致，这与全身性癫痫发作的症状学相符。为了研究治疗相关性，我们分析了21例接受深部脑刺激（DBS）治疗全身性癫痫的IGE患者的数据。DBS后癫痫发作频率中位数降低了90%，刺激部位与丘脑中央中核的一个IGE网络峰值相交。总之，这项研究有助于统一IGE先前的研究结果，并确定一个脑网络靶点，该靶点可在脑刺激控制全身性癫痫的临床试验中进行测试。