Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Mol Cell. 2017 Jan 5;65(1):1-2. doi: 10.1016/j.molcel.2016.12.017.
Thousands of long noncoding RNAs (lncRNAs) have been annotated, yet their functions remain unclear. Recent studies-including Schlackow et al. (2017) in this issue of Molecular Cell-using orthogonal methods investigated the expression and functions of lncRNAs, resulting in deeper appreciation for the salient differences between lncRNAs and mRNAs and the roles lncRNAs serve.
数以千计的长非编码 RNA（lncRNA）已经被注释，但它们的功能仍然不清楚。最近的研究——包括 Schlackow 等人（2017）在本期《分子细胞》中的研究——使用正交方法研究了 lncRNA 的表达和功能，从而更深入地了解了 lncRNA 和 mRNA 之间的显著差异，以及 lncRNA 所起的作用。
