Xiong Jianwen, Zhang Xiaoqiang, Chen Xianglai, Wei Yiping, Lu De-Guo, Han Yun-Wei, Xu Jianjun, Yu Dongliang
Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province 330006, P. R. China.
Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
Oncotarget. 2017 Feb 21;8(8):13157-13165. doi: 10.18632/oncotarget.14483.
Notch signalling is aberrantly activated in human non-small cell lung cancer (NSCLC). Nevertheless, the prognostic roles of mRNA expression of four Notch receptors in NSCLC patients remain elusive. In this report, we reported the prognostic roles of Notch receptors in a total of 1,926 NSCLC patients through "The Kaplan-Meier plotter" (KM plotter) database which is capable to assess the effect of 22,277 genes on survival of NSCLC patients. We found that mRNA high expression level of Notch1 was associated with better overall survival (OS) for all NSCLC patients, hazard ratio (HR) 0.78 (0.69-0.89), p=0.00019, better OS in adenocarcinoma (Ade) patients, HR 0.59 (0.46-0.75), p=1.5e-05, as well as in squamous cell carcinoma (SCC) patients, HR 0.78 (0.62-0.99), p=0.044. mRNA high expression levels of Notch2 and Notch3 were associated with worsen OS for all NSCLC patients, as well as in Ade, but not in SCC patients. mRNA high expression level of Notch4 was not found to be associated with to OS for all NSCLC patients. In addition, mRNA high expression levels of Notch2, Notch3, but Notch4 are significantly associated with the NSCLC patients who have different smoking status. Our results indicate that mRNA expression of Notch receptors may have distinct prognostic values in NSCLC patients. These results will benefit for developing tools to accurately predict the prognosis of NSCLC patients.
Notch信号通路在人类非小细胞肺癌（NSCLC）中异常激活。然而，四种Notch受体的mRNA表达在NSCLC患者中的预后作用仍不清楚。在本报告中，我们通过 “Kaplan-Meier绘图仪”（KM绘图仪）数据库报告了Notch受体在总共1926例NSCLC患者中的预后作用，该数据库能够评估22277个基因对NSCLC患者生存的影响。我们发现，Notch1的mRNA高表达水平与所有NSCLC患者更好的总生存期（OS）相关，风险比（HR）为0.78（0.69 - 0.89），p = 0.00019，在腺癌（Ade）患者中OS更好，HR为0.59（0.46 - 0.75），p = 1.5e - 05，在鳞状细胞癌（SCC）患者中也是如此，HR为0.78（0.62 - 0.99），p = 0.044。Notch2和Notch3的mRNA高表达水平与所有NSCLC患者以及Ade患者的OS恶化相关，但在SCC患者中并非如此。未发现Notch4的mRNA高表达水平与所有NSCLC患者的OS相关。此外，Notch2、Notch3但Notch4的mRNA高表达水平与具有不同吸烟状态的NSCLC患者显著相关。我们的结果表明，Notch受体的mRNA表达在NSCLC患者中可能具有不同的预后价值。这些结果将有助于开发准确预测NSCLC患者预后的工具。
