Dai Jie, Yang Ping, Cox Angela, Jiang Gening
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Minnesota, United States of America.
Oncotarget. 2017 Mar 14;8(11):18513-18524. doi: 10.18632/oncotarget.14505.
Chronic obstructive pulmonary disease (COPD) and lung cancer are devastating pulmonary diseases that commonly coexist and present a number of clinical challenges. COPD confers a higher risk for lung cancer development, but available chemopreventive measures remain rudimentary. Current studies have shown a marked benefit of cancer screening in the COPD population, although challenges remain, including the common underdiagnosis of COPD. COPD-associated lung cancer presents distinct clinical features. Treatment for lung cancer coexisting with COPD is challenging as COPD may increase postoperative morbidities and decrease survival. In this review, we outline current progress in the understanding of the clinical association between COPD and lung cancer, and suggest possible cancer prevention strategies in this patient population.
慢性阻塞性肺疾病（COPD）和肺癌是常见的、同时存在且带来诸多临床挑战的严重肺部疾病。COPD会增加肺癌发生风险，但现有的化学预防措施仍很基础。目前的研究表明，癌症筛查对COPD人群有显著益处，尽管仍存在挑战，包括COPD常见的诊断不足问题。COPD相关肺癌具有独特的临床特征。COPD可能会增加术后发病率并降低生存率，因此，同时患有COPD和肺癌的治疗颇具挑战性。在本综述中，我们概述了目前对COPD和肺癌临床关联的认识进展，并提出了针对该患者群体可能的癌症预防策略。
