Tun Tin A, Baskaran Mani, Tan Shayne S, Perera Shamira A, Aung Tin, Husain Rahat
Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.
Singapore Eye Research Institute and Singapore National Eye Centre, Singapore 2Duke-NUS Graduate Medical School, National University of Singapore, Singapore.
Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):59-64. doi: 10.1167/iovs.16-20886.
To evaluate the diagnostic performance of the anterior segment angle-to-angle scan of the Cirrus high-definition optical coherence tomography (HD-OCT) in detecting eyes with closed angles.
All subjects underwent dark-room gonioscopy by an ophthalmologist. A technician performed anterior segment imaging with Cirrus (n = 202) and Visante OCT (n = 85) under dark-room conditions. All eyes were categorized by two masked graders as per number of closed quadrants. Each quadrant of anterior chamber angle was categorized as a closed angle if posterior trabecular meshwork could not be seen on gonioscopy or if there was any irido-corneal contact anterior to scleral spur in Cirrus and Visante images. An eye was graded as having a closed angle if two or more quadrants were closed. Agreement and area under the curve (AUC) were performed.
There were 50 (24.8%) eyes with closed angles. The agreements of closed-angle diagnosis (by eye) between Cirrus HD-OCT and gonioscopy (k = 0.59; 95% confidence interval (CI) 0.45-0.72; AC1 = 0.76) and between Cirrus and Visante OCT (k = 0.65; 95% CI 0.48-0.82, AC1 = 0.77) were moderate. The AUC for diagnosing the eye with gonioscopic closed angle by Cirrus HD-OCT was good (AUC = 0.86; sensitivity = 83.33; specificity = 77.78). The diagnostic performance of Cirrus HD-OCT in detecting the eyes with closed angles was similar to that of Visante (AUC 0.87 vs. 0.9, respectively; P = 0.51).
The anterior segment angle-to-angle scans of Cirrus HD-OCT demonstrated similar diagnostic performance as Visante in detecting gonioscopic closed angles. The agreement between Cirrus and gonioscopy for detecting eyes with closed angles was moderate.
评估Cirrus高清光学相干断层扫描（HD - OCT）眼前节角对角度扫描在检测闭角型眼中的诊断性能。
所有受试者均由眼科医生进行暗室房角镜检查。一名技术人员在暗室条件下使用Cirrus（n = 202）和Visante OCT（n = 85）进行眼前节成像。两名盲法分级人员根据闭象限数量对所有眼睛进行分类。如果在房角镜检查中看不到后小梁网，或者在Cirrus和Visante图像中巩膜突前方存在任何虹膜 - 角膜接触，则将前房角的每个象限分类为闭角。如果两个或更多象限为闭角，则将一只眼睛分级为闭角型。进行一致性分析和曲线下面积（AUC）分析。
有50只（24.8%）眼睛为闭角型。Cirrus HD - OCT与房角镜检查之间（按眼睛）闭角诊断的一致性（k = 0.59；95%置信区间（CI）0.45 - 0.72；AC1 = 0.76）以及Cirrus和Visante OCT之间（k = 0.65；95% CI 0.48 - 0.82，AC1 = 0.77）为中等程度。Cirrus HD - OCT诊断房角镜检查闭角型眼的AUC良好（AUC = 0.86；敏感性 = 83.33；特异性 = 77.78）。Cirrus HD - OCT在检测闭角型眼中的诊断性能与Visante相似（AUC分别为0.87和0.9；P = 0.51）。
Cirrus HD - OCT眼前节角对角度扫描在检测房角镜检查闭角型眼方面显示出与Visante相似的诊断性能。Cirrus与房角镜检查在检测闭角型眼方面的一致性为中等程度。
