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老年患者的乳房重建:风险因素、临床结果及美学效果

Breast Reconstruction in Elderly Patients: Risk Factors, Clinical Outcomes, and Aesthetic Results.

作者信息

Laporta Rosaria, Sorotos Michail, Longo Benedetto, Santanelli di Pompeo Fabio

机构信息

Department of Plastic Surgery, "Sapienza" University of Rome, Sant'Andrea Hospital, Roma, Italy.

出版信息

J Reconstr Microsurg. 2017 May;33(4):257-267. doi: 10.1055/s-0036-1597822. Epub 2017 Jan 6.

Abstract

Correlation among age, clinical, and aesthetic outcomes in implant-based and autologous breast reconstructions was investigated.  Between 2004 and 2014, a retrospective study was performed on patients who underwent reconstruction following mastectomy. Patients were divided in group A (< 50 years), group B (≥ 50-59 years), group C (≥ 60-69 years), and group D (≥ 70 years). Demographics, comorbidities, American Society of Anesthesiologists (ASA) class, and length of stay were assessed using chi-square and Kruskal-Wallis analysis considering  ≤ 0.05 as significant. Pre- and postoperative photographs were taken to grade aesthetic results by patients and blinded plastic surgery team.  A total of 993 patients underwent 1,251 breast reconstructions, of which 356 (28.5%) were implant-based, 402 (32.1%) pedicled-flap, 445 (35.6%) free-flap, and 48 (3.8%) fat-graft reconstructions. There were 316 (25.2%) complications, of which 124 (34.8%) in implant-based, 74 (18.4%) in pedicled-flap, 111 (24.9%) in free-flap, and 2 (4.2%) in fat-graft reconstructions. Mean length of stay was 5.4 days without significant difference between age groups ( = 0.357). The incidence of overall complications was not significantly related to age, ASA class, smoking history, and previous radiotherapy. Body mass index was a significant predictor ( = 0.001), but odds ratio (OR: 1.2) demonstrated only a minimal increase in risk. Implant-based reconstruction was associated with a higher risk for complications compared with the other ones (OR: 2.5,  = 0.001). Patient and surgeon aesthetic surveys demonstrated an overall positive opinion in all age groups for each reconstructive option.  Advanced age should not be considered a risk factor for breast reconstruction, while implant-based technique was associated with a higher risk for complications compared with autologous that may provide older women with greater benefits.

摘要

研究了基于植入物和自体乳房重建中年龄、临床及美学结果之间的相关性。2004年至2014年期间,对乳房切除术后接受重建的患者进行了一项回顾性研究。患者被分为A组(<50岁)、B组(≥50 - 59岁)、C组(≥60 - 69岁)和D组(≥70岁)。使用卡方检验和Kruskal - Wallis分析评估人口统计学、合并症、美国麻醉医师协会(ASA)分级及住院时间,将P≤0.05视为有统计学意义。术前和术后均拍摄照片,由患者和不知情的整形手术团队对美学结果进行评分。共有993例患者接受了1251次乳房重建,其中356例(28.5%)为基于植入物的重建,402例(32.1%)为带蒂皮瓣重建,445例(35.6%)为游离皮瓣重建,48例(3.8%)为脂肪移植重建。发生并发症316例(25.2%),其中基于植入物的重建中有124例(34.8%),带蒂皮瓣重建中有74例(18.4%),游离皮瓣重建中有111例(24.9%),脂肪移植重建中有2例(4.2%)。平均住院时间为5.4天,各年龄组之间无显著差异(P = 0.357)。总体并发症发生率与年龄、ASA分级、吸烟史及既往放疗无显著相关性。体重指数是一个显著的预测因素(P = 0.001),但优势比(OR:1.2)显示风险仅略有增加。与其他重建方式相比,基于植入物的重建并发症风险更高(OR:2.5,P = 0.001)。患者和外科医生的美学调查显示,所有年龄组对每种重建方式总体评价均为积极。高龄不应被视为乳房重建的危险因素,而与自体重建相比,基于植入物的技术并发症风险更高,自体重建可能为老年女性带来更大益处。

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