Laporta Rosaria, Sorotos Michail, Longo Benedetto, Santanelli di Pompeo Fabio
Department of Plastic Surgery, "Sapienza" University of Rome, Sant'Andrea Hospital, Roma, Italy.
J Reconstr Microsurg. 2017 May;33(4):257-267. doi: 10.1055/s-0036-1597822. Epub 2017 Jan 6.
Correlation among age, clinical, and aesthetic outcomes in implant-based and autologous breast reconstructions was investigated. Between 2004 and 2014, a retrospective study was performed on patients who underwent reconstruction following mastectomy. Patients were divided in group A (< 50 years), group B (≥ 50-59 years), group C (≥ 60-69 years), and group D (≥ 70 years). Demographics, comorbidities, American Society of Anesthesiologists (ASA) class, and length of stay were assessed using chi-square and Kruskal-Wallis analysis considering ≤ 0.05 as significant. Pre- and postoperative photographs were taken to grade aesthetic results by patients and blinded plastic surgery team. A total of 993 patients underwent 1,251 breast reconstructions, of which 356 (28.5%) were implant-based, 402 (32.1%) pedicled-flap, 445 (35.6%) free-flap, and 48 (3.8%) fat-graft reconstructions. There were 316 (25.2%) complications, of which 124 (34.8%) in implant-based, 74 (18.4%) in pedicled-flap, 111 (24.9%) in free-flap, and 2 (4.2%) in fat-graft reconstructions. Mean length of stay was 5.4 days without significant difference between age groups ( = 0.357). The incidence of overall complications was not significantly related to age, ASA class, smoking history, and previous radiotherapy. Body mass index was a significant predictor ( = 0.001), but odds ratio (OR: 1.2) demonstrated only a minimal increase in risk. Implant-based reconstruction was associated with a higher risk for complications compared with the other ones (OR: 2.5, = 0.001). Patient and surgeon aesthetic surveys demonstrated an overall positive opinion in all age groups for each reconstructive option. Advanced age should not be considered a risk factor for breast reconstruction, while implant-based technique was associated with a higher risk for complications compared with autologous that may provide older women with greater benefits.
研究了基于植入物和自体乳房重建中年龄、临床及美学结果之间的相关性。2004年至2014年期间,对乳房切除术后接受重建的患者进行了一项回顾性研究。患者被分为A组(<50岁)、B组(≥50 - 59岁)、C组(≥60 - 69岁)和D组(≥70岁)。使用卡方检验和Kruskal - Wallis分析评估人口统计学、合并症、美国麻醉医师协会(ASA)分级及住院时间,将P≤0.05视为有统计学意义。术前和术后均拍摄照片,由患者和不知情的整形手术团队对美学结果进行评分。共有993例患者接受了1251次乳房重建,其中356例(28.5%)为基于植入物的重建,402例(32.1%)为带蒂皮瓣重建,445例(35.6%)为游离皮瓣重建,48例(3.8%)为脂肪移植重建。发生并发症316例(25.2%),其中基于植入物的重建中有124例(34.8%),带蒂皮瓣重建中有74例(18.4%),游离皮瓣重建中有111例(24.9%),脂肪移植重建中有2例(4.2%)。平均住院时间为5.4天,各年龄组之间无显著差异(P = 0.357)。总体并发症发生率与年龄、ASA分级、吸烟史及既往放疗无显著相关性。体重指数是一个显著的预测因素(P = 0.001),但优势比(OR:1.2)显示风险仅略有增加。与其他重建方式相比,基于植入物的重建并发症风险更高(OR:2.5,P = 0.001)。患者和外科医生的美学调查显示,所有年龄组对每种重建方式总体评价均为积极。高龄不应被视为乳房重建的危险因素,而与自体重建相比,基于植入物的技术并发症风险更高,自体重建可能为老年女性带来更大益处。