Wang Xin, Gao Ming, Zhou Shanshan, Wang Jinwen, Liu Fang, Tian Feng, Jin Jing, Ma Qiang, Xue Xiaodi, Liu Jie, Liu Yuqi, Chen Yundai
Department of Health Statistics, School of Public Health, Fourth Military Medical University, Xi'an, Shanxi Province, China.
Center For Disease Control And Prevention Of The PAP, Beijing, China.
BMC Cardiovasc Disord. 2017 Jan 7;17(1):18. doi: 10.1186/s12872-016-0458-1.
The incidence of young coronary heart disease (CHD, ≤45 years) in China is increasing. Secondary prevention to counter this trend is an important contemporary public health issure.
A total of 5288 patients (≤45 years) diagnosed with CHD and hospitalized at the Chinese PLA General Hospital and Anzhen Hospital, both in Beijing, were enrolled after satisfying the inclusion criteria.
Young CHD patients increased in number from 2010 to 2014, especially men. Among the studied patients, there was no significant change over those years in blood pressure, but heart rate increased significantly (P < 0.05) and body mass index showed a rising trend (P > 0.05). The incidence of hypertension increased from 40.7 to 47.5%, diabetes from 20.3 to 26.1%, and hyperlipidemia from 27.3 to 35.7% (P < 0.05). However, the incidences of smoking and drinking both trended downward (P < 0.05). The levels of total cholesterol and triglycerides also showed a downward trend (P < 0.05), as did levels of low-density lipoprotein, but not to the point of statistical significance (P > 0.05). Mortality during hospitalization decreased significantly from 2010 to 2014 (P < 0.05), but there was no significant improvement in the incidences of cardiac death and major adverse cardiovascular events (MACE) after 1-year follow-up (P > 0.05).
Over the 5 years studied, the overall incidence of cardiac death and MACE for young CHD patients (≤45 years) has shown little improvement. Secondary prevention of young CHD, and its risk factors, as well as appropriate courses of medical treatment must be further elucidated.
中国青年冠心病（CHD，年龄≤45岁）的发病率正在上升。针对这一趋势的二级预防是当代一项重要的公共卫生问题。
共有5288例年龄≤45岁、在北京解放军总医院和安贞医院住院并被诊断为冠心病的患者在满足纳入标准后被纳入研究。
2010年至2014年青年冠心病患者数量增加，尤其是男性。在研究患者中，这些年血压无显著变化，但心率显著增加（P<0.05），体重指数呈上升趋势（P>0.05）。高血压发病率从40.7%增至47.5%，糖尿病从20.3%增至26.1%，高脂血症从27.3%增至35.7%（P<0.05）。然而，吸烟和饮酒的发生率均呈下降趋势（P<0.05）。总胆固醇和甘油三酯水平也呈下降趋势（P<0.05），低密度脂蛋白水平也是如此，但未达到统计学意义（P>0.05）。2010年至2014年住院期间死亡率显著下降（P<0.05），但1年随访后心脏性死亡和主要不良心血管事件（MACE）的发生率无显著改善（P>0.05）。
在研究的5年中，青年冠心病患者（≤45岁）心脏性死亡和MACE的总体发生率几乎没有改善。青年冠心病及其危险因素的二级预防以及适当的治疗方案必须进一步阐明。
