Klouchek E, Popov A
Eksp Med Morfol. 1989;28(3):47-50.
Some biochemical, pathohistological and ultrastructural changes in liver after the action of single intraperitoneal administration of furosemide (Furantryl-Pharmachim) in a dose of 300 mg/kg of body mass were studied in male white rats of Wistar strain. The results from the performed experiments established increased activity of serum enzymes GOT, GPT, GGT, alkaline phosphatase as well as low values of serum cholinesterase. Pathohistologic and electron microscopy examination discovered liver damage with typical congestive changes mainly--manifested local erythremia and a reduced fluid content of the blood in the liver with blockage in the sinusoidal pole of hepatocytes; there were also focal micronecrosis, considerable reduction of glycogen and slight centrolobular steatosis. The possibility is discussed for usage of hepatotoxicity, induced by furosemide, in examining the effects of some drugs with potential hepatoprotective activity.
在Wistar品系雄性大白鼠身上，研究了单次腹腔注射剂量为300毫克/千克体重的速尿（呋喃苯胺酸-保加利亚制药厂生产）后肝脏的一些生化、病理组织学和超微结构变化。实验结果显示，血清酶谷草转氨酶（GOT）、谷丙转氨酶（GPT）、γ-谷氨酰转肽酶（GGT）以及碱性磷酸酶的活性增加，同时血清胆碱酯酶值降低。病理组织学和电子显微镜检查发现肝脏损伤，主要表现为典型的充血性变化——局部红细胞增多，肝脏血液液体含量减少，肝细胞窦状隙极区阻塞；还存在局灶性微坏死、糖原大量减少以及轻度小叶中心性脂肪变性。文中讨论了利用速尿诱导的肝毒性来检测某些具有潜在肝保护活性药物效果的可能性。
