Gilani A H, Janbaz K H
Department of Pharmacology, Aga Khan University Medical College, Karachi.
J Pak Med Assoc. 1994 Mar;44(3):65-8.
The hepatoprotective activity of crude extract of artemisia scoparia (aerial parts) was investigated against experimentally produced hepatic damage using carbon tetrachloride (CCl4) as a model hepatotoxin. CCl4 at the dose of 1.5 ml/kg, produced liver damage in rats as manifested by the rise in serum levels of AST and ALT to 395 +/- 110 and 258 +/- 61 IU/l (mean +/- SEM; n = 10) respectively, compared to control values of 106 +/- 15 and 26 +/- 04. Pretreatment of rats with plant extract (150 mg/kg) significantly lowered (P < 0.01), the respective serum GOT and GPT levels to 93 +/- 05 and 27 +/- 03 IU/l, indicating hepatoprotective action. Pentobarbital sodium (75 mg/kg)-induced sleeping time in mice was found to be 140.8 +/- 1.5 min (n = 10) which was similar (P > 0.05) to that obtained in the group of animals pretreated with the plant extract (139.9 +/- 1.8 min). CCl4 treatment extended the pentobarbital sleeping time to 212.2 +/- 19.1 min and pretreatment of animals with plant extract reversed the CCl4-induced prolongation in pentobarbital sleeping time to 143.9 +/- 5.5 min (P < 0.001) which further confirms the protective action of the plant extract against CCl4-induced liver damage. These data indicate that the plant artemisia scoparia is hepatoprotective and validate the folkloric use of this plant in liver damage.
以四氯化碳（CCl4）作为肝毒素模型，研究了茵陈蒿（地上部分）粗提取物对实验性肝损伤的保肝活性。剂量为1.5 ml/kg的CCl4可导致大鼠肝损伤，表现为血清AST和ALT水平分别升至395±110和258±61 IU/l（平均值±标准误；n = 10），而对照组值分别为106±15和26±04。用植物提取物（150 mg/kg）预处理大鼠可显著降低（P < 0.01）血清GOT和GPT水平，分别降至93±05和27±03 IU/l，表明具有保肝作用。戊巴比妥钠（75 mg/kg）诱导的小鼠睡眠时间为140.8±1.5分钟（n = 10），与用植物提取物预处理的动物组（139.9±1.8分钟）相似（P > 0.05）。CCl4处理使戊巴比妥睡眠时间延长至212.2±19.1分钟，用植物提取物预处理动物可将CCl4诱导的戊巴比妥睡眠时间延长逆转至143.9±5.5分钟（P < 0.001），这进一步证实了植物提取物对CCl4诱导的肝损伤的保护作用。这些数据表明茵陈蒿具有保肝作用，并验证了该植物在肝损伤方面的民间药用价值。
