基于一项涉及17469名受试者的荟萃分析，MTHFR基因C677T多态性与急性淋巴细胞白血病风险之间的关联。
The association between MTHFR gene C677T polymorphism and ALL risk based on a meta-analysis involving 17,469 subjects.
作者信息
Zhang Beibei, Zhang Weiming, Yan Liang, Wang Daogang
机构信息
Department of Molecular Microbiology, Oslo University Hospital, Oslo, Norway.
Department of Oncology, The Affiliated Hospital of Binzhou Medical College, Binzhou, PR China.
出版信息
Clin Chim Acta. 2017 Mar;466:85-92. doi: 10.1016/j.cca.2017.01.001. Epub 2017 Jan 3.
BACKGROUND
The methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism is closely related to the acute lymphoblastic leukaemia (ALL) indicated by many previous epidemiologic studies. However, their conclusions were still conflicting.
METHODS
Our aim is to evaluate their associations using a more comprehensive updated meta-analysis. Electronic searches were conducted to select published studies prior to February, 2016.
RESULTS
Totally, 39 case-control studies including 6551 ALL cases and 10,918 controls were selected in current meta-analysis. The association was detected significantly between MTHFR C677T polymorphism and ALL reducing susceptibility.
CONCLUSIONS
Our results indicate that the MTHFR C677T polymorphism may be a promising ALL biomarker and studies to explore the protein levels of the variants and their functional role are required for the definitive conclusions.
背景
此前许多流行病学研究表明，亚甲基四氢叶酸还原酶（MTHFR）基因C677T多态性与急性淋巴细胞白血病（ALL）密切相关。然而，他们的结论仍存在冲突。
方法
我们的目的是通过更全面的最新荟萃分析来评估它们之间的关联。进行电子检索以选择2016年2月之前发表的研究。
结果
在当前的荟萃分析中，共选择了39项病例对照研究，包括6551例ALL病例和10918例对照。检测到MTHFR C677T多态性与ALL易感性降低之间存在显著关联。
结论
我们的结果表明，MTHFR C677T多态性可能是一种有前景的ALL生物标志物，需要开展研究以探索变体的蛋白质水平及其功能作用，从而得出明确结论。
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