Frikha Rim
Faculty of Medicine, University of Sfax, Sfax-Tunisia.
Department of Medical Genetics, Hedi Chaker University Teaching Hospital, Sfax-Tunisia.
J Oncol Pharm Pract. 2020 Oct;26(7):1598-1610. doi: 10.1177/1078155219900914. Epub 2020 Feb 18.
The methylenetetrahydrofolate reductase gene C677T polymorphism is closely related to the acute lymphoblastic leukemia. Several case-control studies have investigated this association; however, no conclusions could be drawn. A comprehensive updated meta-analysis is established to explain these contradictions and clarify the overall impact of this variant on the susceptibility to acute lymphoblastic leukemia.
Electronic searches were conducted to select published studies prior to June 2018. Pooled odds ratios and stratification analysis were performed under different genetic comparison models, age, and ethnicity.
Totally, 66 case-control studies including 9619 acute lymphoblastic leukemia cases and 17,396 controls were selected. Our analyses showed that methylenetetrahydrofolate reductase C677T polymorphism was protective mainly in Asian and European countries, under all genetic models and regardless of age, but leukemogenic in mixed population.
Thus, C677T polymorphism may be a promising acute lymphoblastic leukemia biomarker, but they should be interpreted with caution considering other factors such as folic acid intake, gene-gene and gene-environment interactions.
亚甲基四氢叶酸还原酶基因C677T多态性与急性淋巴细胞白血病密切相关。多项病例对照研究对这种关联进行了调查；然而，尚未得出结论。开展一项全面的更新荟萃分析以解释这些矛盾，并阐明该变异对急性淋巴细胞白血病易感性的总体影响。
进行电子检索以筛选2018年6月之前发表的研究。在不同的基因比较模型、年龄和种族条件下进行合并比值比和分层分析。
共纳入66项病例对照研究，包括9619例急性淋巴细胞白血病病例和17396例对照。我们的分析表明，在所有基因模型下且无论年龄如何，亚甲基四氢叶酸还原酶C677T多态性在亚洲和欧洲国家主要具有保护作用，但在混合人群中具有致白血病作用。
因此，C677T多态性可能是一种有前景的急性淋巴细胞白血病生物标志物，但考虑到其他因素如叶酸摄入、基因-基因和基因-环境相互作用，应谨慎解读。
