Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W Green Street, 61801, USA.
Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, University of North Carolina at Chapel Hill, Chapel Hill, 27599, USA; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, University of North Carolina at Chapel Hill, Chapel Hill, 27599, USA.
J Control Release. 2017 Oct 10;263:211-222. doi: 10.1016/j.jconrel.2016.11.034. Epub 2017 Jan 3.
The past several decades have witnessed the rapid development of nanomedicine (NM) which integrates the advancement of various interdisciplinary areas of science, engineering, and medicine. While a few clinical successes of NM greatly change the landscape of disease diagnosis and treatment, there are several areas of NM remaining to be explored. One such area is the complicated interactions between the NM and biological environment post administration, and how such interaction affects the biological performance of NM. Here, we review the recent progresses on this topic and discuss the interaction of NM with microscopic biomolecules, cells, and the macroscopic in vivo environment. The complete profiling of the bio/nanomaterials interface and interaction should have profound impact on the optimization and de novo design of new NM with better in vivo performance.
过去几十年见证了纳米医学（NM）的快速发展，它整合了多个跨学科领域的科学、工程和医学的进步。虽然 NM 的一些临床成功极大地改变了疾病诊断和治疗的格局，但 NM 仍有几个领域有待探索。其中一个领域是 NM 给药后与生物环境之间复杂的相互作用，以及这种相互作用如何影响 NM 的生物学性能。在这里，我们回顾了这一主题的最新进展，并讨论了 NM 与微观生物分子、细胞和宏观体内环境的相互作用。对生物/纳米材料界面和相互作用的全面分析应该对优化和从头设计具有更好体内性能的新型 NM 产生深远的影响。
