神经布鲁菌病：来自宏基因组下一代测序的意外答案。
Neurobrucellosis: Unexpected Answer From Metagenomic Next-Generation Sequencing.
机构信息
Department of Pediatrics, Division of Infectious Diseases.
Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles and Keck School of Medicine, University of Southern California, Los Angeles.
出版信息
J Pediatric Infect Dis Soc. 2017 Nov 24;6(4):393-398. doi: 10.1093/jpids/piw066.
Abstract
A diagnosis of brucellosis can be difficult because routine culture and serological methods exhibit variable sensitivity and specificity. We present the use of a metagenomic next- generation sequencing assay to diagnose a case of neurobrucellosis from cerebrospinal fluid, resulting in the institution of appropriate antibiotic treatment and a favorable clinical outcome.
摘要
布鲁氏菌病的诊断较为困难，因为常规的培养和血清学方法的灵敏度和特异性存在差异。我们介绍了使用宏基因组下一代测序检测方法诊断一例来自脑脊液的神经型布鲁氏菌病，从而实施了适当的抗生素治疗，并获得了良好的临床转归。
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