Dawar Farman Ullah, Wu Junjie, Zhao Lijuan, Khattak Muhammad Nasir Khan, Mei Jie, Lin Li
College of Fisheries, Huazhong Agricultural University Wuhan, Hubei, China.
College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, China.
J Leukoc Biol. 2017 Apr;101(4):823-826. doi: 10.1189/jlb.3RU1116-477R. Epub 2017 Jan 6.
Cyclophilin A (CypA), a well-recognized receptor for anti-inflammatory drug cyclosporine A (CsA) is a ubiquitous and multifunctional protein. Beside the diverse intracellular functions, CypA is secreted against inflammatory stimuli, where it activates and attracts leukocytes via CD147 to the stimulus site. Interestingly, it synergizes with other factors to induce leukocyte migration in different animals. However, the silencing and inhibition of CypA or CD147 inhibits leukocytes chemotaxis and inflammation. This review focuses on the advances made in understanding the mechanism of CypA-dependent leukocytes chemotaxis and hence, recognition of this factor as a possible therapeutic target in inflammatory diseases.
亲环素A（CypA）是抗炎药物环孢素A（CsA）广为人知的受体，是一种普遍存在的多功能蛋白质。除了多种细胞内功能外，CypA在炎症刺激下会分泌，在那里它通过CD147激活并吸引白细胞到刺激部位。有趣的是，它与其他因素协同作用，诱导不同动物体内的白细胞迁移。然而，CypA或CD147的沉默和抑制会抑制白细胞趋化性和炎症。本综述重点关注在理解CypA依赖性白细胞趋化性机制方面取得的进展，因此，将该因子识别为炎症性疾病中可能的治疗靶点。
