College of Fisheries, Huazhong Agricultural University, Wuhan, Hubei, China.
Department of Zoology, Hazara University, Mansehra, Khyber Pakhtunkhwa, Pakistan.
J Leukoc Biol. 2017 Oct;102(4):989-992. doi: 10.1189/jlb.3RU0317-090RR. Epub 2017 Jul 20.
Cyclophilin A (CypA), a peptidylprolyl - isomerase, is a ubiquitous and multifunctional protein. In addition to its role as a host-cell receptor for cyclosporine A, CypA has diverse functions in inflammatory conditions and diseases. CypA secreted in response to inflammatory stimuli binds to the cell surface via its receptor CD147 and induces secretion of various inflammatory cytokines. However, silencing and inhibition of either CypA or CD147 inhibits inflammatory cytokine expression and inflammation. This report reviews the literature related to the mechanism of CypA-dependent cytokine secretion and discusses this factor as a possible therapeutic target in inflammatory diseases.
亲环素 A（CypA）是一种肽基脯氨酰顺反异构酶，是一种普遍存在且多功能的蛋白质。除了作为环孢素 A 的宿主细胞受体外，CypA 在炎症条件和疾病中具有多种功能。CypA 作为对炎症刺激的反应而分泌，通过其受体 CD147 与细胞表面结合，并诱导各种炎症细胞因子的分泌。然而，沉默或抑制 CypA 或 CD147 均可抑制炎症细胞因子的表达和炎症。本报告回顾了与 CypA 依赖性细胞因子分泌机制相关的文献，并讨论了将该因子作为炎症性疾病的潜在治疗靶点的可能性。
