循环无细胞 DNA 中的 DNA 甲基化特征作为癌症早期检测的生物标志物。
DNA methylation signatures in circulating cell-free DNA as biomarkers for the early detection of cancer.
机构信息
Key Laboratory of Genomic and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
出版信息
Sci China Life Sci. 2017 Apr;60(4):356-362. doi: 10.1007/s11427-016-0253-7. Epub 2017 Jan 5.
Detecting cell-free DNA (cfDNA) or circulating tumor DNA (ctDNA) in plasma or serum could serve as a "liquid biopsy", which would be useful for numerous diagnostic applications. cfDNA methylation detection is one of the most promising approaches for cancer risk assessment. Here, we reviewed the literature related to the use of serum or plasma circulating cell-free DNA for cancer diagnosis in the early stage and their power as future biomarkers.
检测血浆或血清中的无细胞游离 DNA (cfDNA) 或循环肿瘤 DNA (ctDNA) 可以作为一种“液体活检”，这对于许多诊断应用非常有用。cfDNA 甲基化检测是癌症风险评估最有前途的方法之一。在这里，我们回顾了有关使用血清或血浆循环无细胞游离 DNA 进行早期癌症诊断及其作为未来生物标志物潜力的文献。
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