Xia Shusen, Liu Lixin, Zhou Yi, Zhu Yanbin, Dai Qian, Peng Hong
The Second Department of Gastrointestinal Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Department of Gastrointestinal Surgery, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
Discov Oncol. 2025 Aug 18;16(1):1575. doi: 10.1007/s12672-025-03394-2.
Recent research has highlighted ctDNA as a crucial tool for screening, monitoring, and treating colorectal cancer, gaining significant attention. This study aims to map the research landscape via bibliometric analysis, identifying future trends and key areas of interest. We collected articles and reviews on ctDNA and colorectal cancer from the Web of Science Core Collection and Scopus, conducting bibliometric analysis and visualization using VOSviewer, CiteSpace, and R packages. A total of 1,730 publications were included in the bibliometric analysis. Of these, 325 were unique to WOS and 639 were unique to SCOPUS. The United States and China led in publication volume with 555 and 306 papers, respectively, while the United States and Italy had the highest citation counts, with 39,142 and 21,417 citations, respectively. The University of Texas MD Anderson Cancer Center was the most prolific institution. The journals Cancers and Frontiers in Oncology were the most frequently published. Bardelli A stood out as the most prolific and cited author. Cluster analysis revealed trending topics such as "minimal residual disease," "adjuvant chemotherapy," and "recurrence." This bibliometric analysis highlights significant advancements and emerging trends in the clinical application of ctDNA for colorectal cancer. The identified hotspots deserve further attention from researchers in this field.
最近的研究突出了循环肿瘤DNA（ctDNA）作为筛查、监测和治疗结直肠癌的关键工具，受到了广泛关注。本研究旨在通过文献计量分析描绘研究概况，确定未来趋势和关键关注领域。我们从科学网核心合集和Scopus数据库收集了关于ctDNA和结直肠癌的文章及综述，使用VOSviewer、CiteSpace和R包进行文献计量分析和可视化。文献计量分析共纳入1730篇出版物。其中，科学网（WOS）独有的有325篇，Scopus独有的有639篇。美国和中国的发文量领先，分别为555篇和306篇，而美国和意大利的被引频次最高，分别为39142次和21417次。德克萨斯大学MD安德森癌症中心是发文最多的机构。《Cancers》和《肿瘤学前沿》是发表文章最频繁的期刊。巴尔德利·A是发文量和被引频次最高的作者。聚类分析揭示了“微小残留病”“辅助化疗”和“复发”等热门话题。这项文献计量分析突出了ctDNA在结直肠癌临床应用中的重大进展和新趋势。这些确定的热点值得该领域研究人员的进一步关注。
