Argiolas A, Melis M R, Gessa G L
Department of Neurosciences, University of Cagliari, Italy.
Eur J Pharmacol. 1989 Aug 3;166(3):515-8. doi: 10.1016/0014-2999(89)90366-x.
The effect of i.p. injection of the calcium channel inhibitors, verapamil, flunarizine, nifedipine, nimodipine and nicardipine, on penile erection and yawning induced by the dopamine agonist, apomorphine, or by oxytocin was studied in male rats. The five compounds antagonized in a dose-dependent manner the behavioral responses induced either by apomorphine or oxytocin. Nimodipine and nicardipine were found to be the most potent, being active in doses between 5 and 20 mg/kg, while nifedipine, verapamil and flunarizine were active in doses higher than 15 mg/kg. The results suggest that calcium is involved in the expression of the above-mentioned behavioural responses.
研究了腹腔注射钙通道抑制剂维拉帕米、氟桂利嗪、硝苯地平、尼莫地平和尼卡地平对多巴胺激动剂阿扑吗啡或催产素诱导的雄性大鼠阴茎勃起和打哈欠的影响。这五种化合物以剂量依赖性方式拮抗阿扑吗啡或催产素诱导的行为反应。发现尼莫地平和尼卡地平效力最强，在5至20毫克/千克的剂量下具有活性，而硝苯地平、维拉帕米和氟桂利嗪在高于15毫克/千克的剂量下具有活性。结果表明钙参与了上述行为反应的表达。
