Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA.
Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):850-857. doi: 10.1016/j.bbamcr.2016.12.023. Epub 2017 Jan 5.
Ca is a ubiquitous intracellular messenger that regulates numerous physiological activities in humans, animals, plants, and bacteria. Cytosolic Ca is kept at a low level, but subcellular organelles such as the endoplasmic reticulum (ER) and Golgi apparatus maintain high-concentration Ca stores. Under resting conditions, store Ca homeostasis is dynamically regulated to equilibrate between active Ca uptake and passive Ca leak processes. The evolutionarily conserved Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) proteins mediate Ca homeostasis and cell death. This review focuses on recent advances in functional and structural analysis of TMBIM proteins in regulation of the two related functions. The roles of TMBIM proteins in pathogen infection and cancer are also discussed with prospects for treatment. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech.
钙是一种普遍存在的细胞内信使，调节人类、动物、植物和细菌的许多生理活动。细胞质中的钙保持在低水平，但内质网（ER）和高尔基体等亚细胞细胞器维持着高浓度的钙储存。在静息状态下，储存钙的动态平衡受到严格调控，以维持活跃的钙摄取和被动钙泄漏过程之间的平衡。进化上保守的跨膜 BAX 抑制剂-1 基序包含（TMBIM）蛋白介导钙稳态和细胞死亡。本综述重点介绍了 TMBIM 蛋白在调节这两种相关功能方面的功能和结构分析的最新进展。还讨论了 TMBIM 蛋白在病原体感染和癌症中的作用，并展望了治疗前景。本文是由 Claus Heizmann、Joachim Krebs 和 Jacques Haiech 编辑的题为“ECS 会议”的特刊的一部分。
