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Antagonizing Bcl-2's BH4 domain in cancer.

作者信息

Vervloessem Tamara, La Rovere Rita, Bultynck Geert

机构信息

KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Campus Gasthuisberg O/N-I bus 802, Leuven, Belgium.

出版信息

Aging (Albany NY). 2015 Oct;7(10):748-9. doi: 10.18632/aging.100828.

DOI:10.18632/aging.100828
PMID:26525307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4637201/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d82/4637201/3eae444b9b51/aging-07-748-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d82/4637201/3eae444b9b51/aging-07-748-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d82/4637201/3eae444b9b51/aging-07-748-g001.jpg

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本文引用的文献

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A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2.一种靶向Bcl-2的BH4结构域的合成肽单独或与靶向Bcl-2的BH3结合口袋的药物联合使用时,可诱导多发性骨髓瘤和滤泡性淋巴瘤细胞凋亡。
Oncotarget. 2015 Sep 29;6(29):27388-402. doi: 10.18632/oncotarget.4489.
2
Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy.用于肺癌治疗的小分子Bcl2 BH4拮抗剂
Cancer Cell. 2015 Jun 8;27(6):852-63. doi: 10.1016/j.ccell.2015.04.010. Epub 2015 May 21.
3
Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.
BDA-366,一种假定的 Bcl-2 BH4 结构域拮抗剂,在多种癌症细胞模型中独立于 Bcl-2 诱导细胞凋亡。
Cell Death Dis. 2020 Sep 17;11(9):769. doi: 10.1038/s41419-020-02944-6.
4
DLBCL Cells with Acquired Resistance to Venetoclax Are Not Sensitized to BIRD-2 But Can Be Resensitized to Venetoclax through Bcl-XL Inhibition.获得 Venetoclax 耐药性的 DLBCL 细胞对 BIRD-2 无敏感性,但可通过 Bcl-XL 抑制重新对 Venetoclax 敏感。
Biomolecules. 2020 Jul 21;10(7):1081. doi: 10.3390/biom10071081.
5
Reciprocal sensitivity of diffuse large B-cell lymphoma cells to Bcl-2 inhibitors BIRD-2 versus venetoclax.弥漫性大B细胞淋巴瘤细胞对Bcl-2抑制剂BIRD-2与维奈克拉的相互敏感性。
Oncotarget. 2017 Dec 4;8(67):111656-111671. doi: 10.18632/oncotarget.22898. eCollection 2017 Dec 19.
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Modulation of Ca Signaling by Anti-apoptotic B-Cell Lymphoma 2 Proteins at the Endoplasmic Reticulum-Mitochondrial Interface.抗凋亡B细胞淋巴瘤2蛋白在内质网-线粒体界面处对钙信号的调节作用
Front Oncol. 2017 May 3;7:75. doi: 10.3389/fonc.2017.00075. eCollection 2017.
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Bcl-2 delays cell cycle through mitochondrial ATP and ROS.Bcl-2通过线粒体ATP和活性氧延缓细胞周期。
Cell Cycle. 2017 Apr 3;16(7):707-713. doi: 10.1080/15384101.2017.1295182. Epub 2017 Feb 22.
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TMBIM-mediated Ca homeostasis and cell death.TMBIM 介导的钙稳态和细胞死亡。
Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):850-857. doi: 10.1016/j.bbamcr.2016.12.023. Epub 2017 Jan 5.
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