Dept. of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.
KWS BioTest, Marine View Office Park, Portishead, Somerset BS20 7AW, UK.
Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):858-864. doi: 10.1016/j.bbamcr.2016.12.024. Epub 2017 Jan 4.
Mitochondria-associated membranes are juxtaposed between the endoplasmic reticulum and mitochondria and have been identified as a critical hub in the regulation of apoptosis and tumor growth. One key function of mitochondria-associated membranes is to provide asylum to a number of proteins with tumor suppressor and oncogenic properties. In this review, we discuss how Ca flux manipulation represents the primary mechanism underlying the action of several oncogenes and tumor-suppressor genes and how these networks might be manipulated to provide novel therapies for cancer. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech.
线粒体相关膜位于内质网和线粒体之间，被认为是调节细胞凋亡和肿瘤生长的关键枢纽。线粒体相关膜的一个关键功能是为具有肿瘤抑制和致癌特性的多种蛋白质提供庇护所。在这篇综述中，我们讨论了 Ca 流操纵如何代表几种癌基因和抑癌基因作用的主要机制，以及如何操纵这些网络为癌症提供新的治疗方法。本文是由 Claus Heizmann、Joachim Krebs 和 Jacques Haiech 编辑的特刊“ECS Meeting”的一部分。
