Tahmasebi Kobra, Amani Reza, Nazari Zahra, Ahmadi Kambiz, Moazzen Sara, Mostafavi Seyed-Ali
Department of Nutrition, School of Paramedicine, Health Research Institute, Diabetes Research Center, Jundishapur University of Medical Sciences, Ahvaz, 61357-15794, Iran.
Food Security Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Biol Trace Elem Res. 2017 Aug;178(2):180-188. doi: 10.1007/s12011-016-0917-7. Epub 2017 Jan 7.
Among various factors influencing mood disorders, the impact of micronutrient deficiencies has attracted a great attention. Zinc deficiency is considered to play a crucial role in the onset and progression of mood disorders in different stages of life. The main objective of this study was to assess the correlation between serum zinc levels and mood disorders in high school female students. This cross-sectional study was conducted on a random sample of 100 representative high school female students. The participants completed 24-h food recall questionnaires to assess the daily zinc intakes. Serum zinc status was assessed using flame atomic absorption spectrometry, and zinc deficiency was defined accordingly. Mood disorders were estimated by calculating the sum of two test scores including Beck's depression inventory (BDI) and hospital anxiety depression scale (HADS) tests. General linear model (GLM) and Pearson's regression test were applied to show the correlation of serum zinc levels and mood disorder scores and the correlation between zinc serum levels and BDI scores, respectively. Dietary zinc intake was higher in subjects with normal zinc concentrations than that of zinc-deficient group (p = 0.001). Serum zinc levels were inversely correlated with BDI and HADS scores (p < 0.05). Each 10 μg/dL increment in serum zinc levels led to 0.3 and 0.01 decrease in depression and anxiety scores, respectively (p < 0.05). Serum zinc levels were inversely correlated with mood disorders including depression and anxiety in adolescent female students. Increasing serum levels of zinc in female students could improve their mood disorders.
在影响情绪障碍的各种因素中，微量营养素缺乏的影响已引起广泛关注。锌缺乏被认为在生命不同阶段情绪障碍的发生和发展中起关键作用。本研究的主要目的是评估高中女生血清锌水平与情绪障碍之间的相关性。这项横断面研究是对100名具有代表性的高中女生进行的随机抽样。参与者完成了24小时食物回忆问卷以评估每日锌摄入量。使用火焰原子吸收光谱法评估血清锌状态，并据此定义锌缺乏。通过计算包括贝克抑郁量表（BDI）和医院焦虑抑郁量表（HADS）测试在内的两项测试分数之和来评估情绪障碍。分别应用一般线性模型（GLM）和皮尔逊回归测试来显示血清锌水平与情绪障碍分数之间的相关性以及血清锌水平与BDI分数之间的相关性。锌浓度正常的受试者的膳食锌摄入量高于锌缺乏组（p = 0.001）。血清锌水平与BDI和HADS分数呈负相关（p < 0.05）。血清锌水平每增加10μg/dL，抑郁和焦虑分数分别降低0.3和0.01（p < 0.05）。血清锌水平与青少年女学生的抑郁和焦虑等情绪障碍呈负相关。提高女学生的血清锌水平可以改善她们的情绪障碍。
