Davis P F, Ryan P A, Osipowicz J, Anderson M J, Sweeney A, Stehbens W E
Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington Hospital, New Zealand.
Exp Mol Pathol. 1989 Oct;51(2):103-10. doi: 10.1016/0014-4800(89)90011-7.
Arteriovenous fistulae between the external jugular vein and the common carotid artery were surgically fashioned in eight sheep. The altered hemodynamics produced morphological changes similar to those observed in human atherosclerosis. The elastica is a major mural component and undergoes considerable structural variation during lesion development. The most significant biochemical changes in the elastin occur in the experimental vein region. These include a quantitative loss particularly in the midregion of the vein and a decrease in the concentration of up to 20% of the crosslinks (desmosine and isodesmosine). There is an increase in the cholesterol content of the elastin purified from both experimental artery and vein. The bound phospholipid was higher in the experimental artery and in the dilated experimental vein. There was a significant time-dependent loss of elastin in the stressed venous tissue.
在八只绵羊身上通过手术制造了颈外静脉与颈总动脉之间的动静脉瘘。改变后的血流动力学产生了与人类动脉粥样硬化中观察到的相似的形态学变化。弹性组织是主要的血管壁成分，在病变发展过程中会发生相当大的结构变化。弹性蛋白最显著的生化变化发生在实验性静脉区域。这些变化包括数量上的减少，特别是在静脉中部区域，交联物（锁链素和异锁链素）的浓度降低了多达20%。从实验性动脉和静脉中纯化出的弹性蛋白的胆固醇含量增加。实验性动脉和扩张的实验性静脉中的结合磷脂含量更高。在受压的静脉组织中，弹性蛋白存在明显的时间依赖性损失。
