Davis P F, Stehbens W E
Biochem Med. 1984 Aug;32(1):15-21. doi: 10.1016/0006-2944(84)90003-6.
The extent of nonenzymatic glycosylation of collagen isolated from sheep carotid arteries and jugular veins was compared. It was found that the level of this modification in the arterial collagen was about 2.7 times higher than that in the venous collagen. Arteriovenous fistulae were established between the common carotid artery and external jugular vein on one side only of six sheep. Sham arteriotomy and phlebotomy were performed on the contralateral vessels. Although there was an increase in the concentration of these ketoamine-linked hexoses in all the tissue samples assayed, a difference of between two- and three-fold was maintained between the arterial and venous tissue. The relationship of this finding to the development of vascular complications and to the level of circulating reducing sugar is discussed.
对从绵羊颈动脉和颈静脉分离出的胶原蛋白的非酶糖基化程度进行了比较。结果发现，动脉胶原蛋白的这种修饰水平比静脉胶原蛋白高约2.7倍。仅在六只绵羊的一侧，在颈总动脉和颈外静脉之间建立动静脉瘘。对另一侧的血管进行假动脉切开术和放血术。尽管在所有检测的组织样本中，这些酮胺连接的己糖浓度都有所增加，但动脉组织和静脉组织之间仍保持着两到三倍的差异。讨论了这一发现与血管并发症发展以及循环还原糖水平的关系。
