Ryan P A, Davis P F, Stehbens W E
Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington Hospital, New Zealand.
Atherosclerosis. 1988 Jun;71(2-3):157-63. doi: 10.1016/0021-9150(88)90139-6.
The external jugular vein and the common carotid artery were anastomosed in 8 sheep. Morphological changes similar to those observed in human atherosclerosis are produced particularly in the venous tissue. There is a significant increase in the collagen content of the dilated mid-segment of the experimental vein. Also there is a positive correlation between post-operative age and the amount of collagen, especially in the distal region of the artery and in the proximal and middle regions of the vein. In both the control and experimental veins the amino acid composition of collagen was very similar. However, the arterial preparations did not exhibit the same degree of purity. Most of the collagen was the type I variant (approx. 80% in arteries and 70% in veins). In the sham-operated veins about 30% of the collagen was type III but it was nearer 17% in the control arteries. Whilst experimental and control arteries had similar proportions of type III collagen, there was a 30% reduction in the experimental veins. Although there was no significant correlation between the proportion of any of the genetic types of collagen and the post-operative age of the animals, there was a strong correlation for the increment in type I in all regions of the experimental vein as a function of time.
在8只绵羊身上进行了颈外静脉与颈总动脉的吻合。特别是在静脉组织中产生了与人类动脉粥样硬化中观察到的类似的形态学变化。实验静脉扩张的中段胶原含量显著增加。术后年龄与胶原量之间也存在正相关，尤其是在动脉的远端区域以及静脉的近端和中段区域。在对照静脉和实验静脉中，胶原的氨基酸组成非常相似。然而，动脉制剂的纯度程度不同。大部分胶原是I型变体（动脉中约80%，静脉中约70%）。在假手术静脉中，约30%的胶原是III型，但在对照动脉中接近17%。虽然实验动脉和对照动脉中III型胶原的比例相似，但实验静脉中减少了30%。尽管任何遗传类型的胶原比例与动物术后年龄之间没有显著相关性，但实验静脉所有区域中I型胶原的增加与时间有很强的相关性。
